Palanza Paola, Parmigiani Stefano
Department of Neuroscience, Unit of Behavioral Biology, University of Parma, 43100 Parma Italy.
Department of Neuroscience, Unit of Behavioral Biology, University of Parma, 43100 Parma Italy.
Neurosci Biobehav Rev. 2017 May;76(Pt A):134-143. doi: 10.1016/j.neubiorev.2017.01.037.
Many aspects of brain functioning exhibit important sex differences that affect behavior, mental health and mental disorders. However, most translational neuroscience research related to animal models of neurobehavioral disorders are carried out in male animals only. Based on published data from our laboratory on the House mouse, we discuss the following issues: (1) sex differences in social behavior of wild-derived mice; (2) artificial selection of laboratory strains and its consequences on social and reproductive competition; (3) sex-dependent effects of common experimental procedures; (4) differential effects of developmental events: the case of endocrine disruption; (5) implications for female models of stress and neurobehavioral disorders. Altogether, this review of data outline the marked differences of male and female responses to different social challenges and evinces the current lack of a relevant female mouse model of social stress. Whilst animal modelling is an important approach towards understanding mechanisms of neurobehavioral disorders, it is evident that data obtained in males may be irrelevant for inferring psychopathology and efficacy of pharmacological treatments for females.
大脑功能的许多方面都表现出重要的性别差异，这些差异会影响行为、心理健康和精神障碍。然而，大多数与神经行为障碍动物模型相关的转化神经科学研究仅在雄性动物中进行。基于我们实验室发表的关于家鼠的数据，我们讨论以下问题：（1）野生来源小鼠社会行为的性别差异；（2）实验室品系的人工选择及其对社会和生殖竞争的影响；（3）常见实验程序的性别依赖性影响；（4）发育事件的差异影响：内分泌干扰的情况；（5）对压力和神经行为障碍雌性模型的影响。总之，这篇数据综述概述了雄性和雌性对不同社会挑战反应的显著差异，并表明目前缺乏相关的社会压力雌性小鼠模型。虽然动物建模是理解神经行为障碍机制的重要方法，但很明显，在雄性动物中获得的数据可能与推断雌性的精神病理学和药物治疗效果无关。
