Sychev Dmitrij Alekseevitch, Shuev Grigorij Nikolaevich, Suleymanov Salavat Shejhovich, Ryzhikova Kristina Anatol'evna, Mirzaev Karin Badavievich, Grishina Elena Anatol'evna, Snalina Natalia Evgenievna, Sozaeva Zhannet Alimovna, Grabuzdov Anton Mikhailovich, Matsneva Irina Andreevna
Department of Internal Medicine and Clinical Pharmacology, Russian Medical Academy of Continuing Professional Education, Ministry of Healthcare, Moscow.
Saiko Russian-Japanese Medical Center, Khabarovsk.
Pharmgenomics Pers Med. 2017 Mar 31;10:93-99. doi: 10.2147/PGPM.S129665. eCollection 2017.
The efficiency and safety of drug therapy depends on the peculiarities of functioning of the P450 cytochrome group and transporting proteins. There are significant differences for single-nucleotide polymorphism (SNP) frequency.
We studied the peculiarities of P450 cytochrome polymorphisms, SLCO1B1 transporting protein, and P-glycoprotein carriage in healthy volunteers in the Nanai ethnic group living in Russia, and compared them to the carriage of SNPs in the Russian population according to literature data.
After performing the real-time polymerase chain reactions on the samples from 70 healthy volunteers from the Nanai group, for the polymorphism we determined 70 CC-genotype carriers. As for the polymorphism, we found 62 AA-genotype carriers and eight AC-genotype carriers. For the polymorphism, we determined 39 GG-genotype carriers and 28 GA-genotype carriers, for the polymorphism 58 GG-genotype carriers and 12 GA-genotype carriers, and for the polymorphism 67 CC-genotype carriers and three CT-genotype carriers. For the polymorphism, the GG genotype had 68 carriers, and the GA genotype two carriers. For the polymorphism, there were 19 CC-genotype carriers and 39 CT-genotype carriers. For the polymorphism, the TT genotype had 41 carriers and the CT genotype 25 carriers. The distribution of genotypes fitted the Hardy-Weinberg equilibrium for all the polymorphisms, except those of . There were also significant differences in allele frequencies for some polymorphisms between the Nanais and the Russians.
In the Nanai population, there are polymorphisms connected with the decrease in safety and efficiency of drug therapy. Studying the ethnic differences might influence the determination of priority in the introduction of pharmacogenetic tests in clinical practice in different regions of Russia.
药物治疗的有效性和安全性取决于细胞色素P450组和转运蛋白的功能特性。单核苷酸多态性（SNP）频率存在显著差异。
我们研究了居住在俄罗斯的那乃族健康志愿者中细胞色素P450多态性、SLCO1B1转运蛋白和P-糖蛋白携带情况，并根据文献数据将其与俄罗斯人群中的SNP携带情况进行比较。
对来自那乃族的70名健康志愿者的样本进行实时聚合酶链反应后，对于 多态性，我们确定了70名CC基因型携带者。至于 多态性，我们发现62名AA基因型携带者和8名AC基因型携带者。对于 多态性，我们确定了39名GG基因型携带者和28名GA基因型携带者，对于 多态性，58名GG基因型携带者和12名GA基因型携带者，对于 多态性，67名CC基因型携带者和3名CT基因型携带者。对于 多态性，GG基因型有68名携带者，GA基因型有2名携带者。对于 多态性，有19名CC基因型携带者和39名CT基因型携带者。对于 多态性，TT基因型有41名携带者，CT基因型有25名携带者。除 多态性外，所有多态性的基因型分布均符合哈迪-温伯格平衡。那乃族和俄罗斯人在某些多态性的等位基因频率上也存在显著差异。
在那乃族人群中，存在与药物治疗安全性和有效性降低相关的多态性。研究种族差异可能会影响俄罗斯不同地区临床实践中引入药物遗传学检测的优先级确定。
