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神经轴索阿片类药物用于分娩、剖宫产和子宫切除术中的镇痛:瑞典的一项问卷调查

Neuraxial opioids as analgesia in labour, caesarean section and hysterectomy: A questionnaire survey in Sweden.

作者信息

Hein Anette, Gillis-Haegerstrand Caroline, Jakobsson Jan G

机构信息

Department of Anaesthesia & Intensive Care, Danderyds Hospital, Stockholm, 182 88, Sweden.

出版信息

F1000Res. 2017 Feb 13;6:133. doi: 10.12688/f1000research.10705.2. eCollection 2017.

DOI:10.12688/f1000research.10705.2
PMID:28435667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5381617/
Abstract

: Neuraxial opioids improve labour analgesia and analgesia after caesarean section (CS) and hysterectomy. Undesirable side effects and difficulties in arranging postoperative monitoring might influence the use of these opioids. The aim of the present survey was to assess the use of intrathecal and epidural morphine in gynaecology and obstetrics in Sweden. : A questionnaire was sent to all anaesthetic obstetric units in Sweden concerning the use and postoperative monitoring of morphine, sufentanil and fentanyl in spinal/epidural anaesthesia. : A total of 32 of 47 (68%) units responded representing 83% of annual CS in Sweden. In CS spinal anaesthesia, 20/32 units use intrathecal morphine, the most common dose of which was 100 μg (17/21). Intrathecal fentanyl (10-20 μg) was used by 21 units and sufentanil (2.5 -10 μg) by 9/32 of the responding units. In CS epidural anaesthesia, epidural fentanyl (50-100 μg) or sufentanil (5-25 μg) were commonly used (25/32), and 12/32 clinics used epidural morphine, the majority of units used a 2 mg dose. Intrathecal morphine for hysterectomy was used by 20/30 units, with 200 μg as the most common dose (9/32). Postoperative monitoring was organized in adherence to the National Guidelines; the patient is monitored postoperative care or an obstetrical ward over 2-6 hours and up-to 12 hours in an ordinary surgical ward. Risk of respiratory depression/difficult to monitor was a reason for not using intrathecal opioids. : Neuraxial morphine is used widely in Sweden in CS and hysterectomy, but is still restricted in some units because of the concern for respiratory depression and difficulties in monitoring.

摘要

椎管内使用阿片类药物可改善分娩镇痛以及剖宫产(CS)和子宫切除术后的镇痛效果。不良反应以及安排术后监测的困难可能会影响这些阿片类药物的使用。本次调查的目的是评估瑞典妇产科中鞘内注射和硬膜外注射吗啡的使用情况。

向瑞典所有产科麻醉单位发送了一份问卷,内容涉及吗啡、舒芬太尼和芬太尼在脊髓/硬膜外麻醉中的使用及术后监测情况。

47个单位中有32个(68%)做出了回应,占瑞典年度剖宫产手术量的83%。在剖宫产脊髓麻醉中,32个单位中的20个使用鞘内注射吗啡,最常用剂量为100μg(21例中有17例)。21个单位使用鞘内注射芬太尼(10 - 20μg),32个做出回应的单位中有9个使用舒芬太尼(2.5 - 10μg)。在剖宫产硬膜外麻醉中,硬膜外注射芬太尼(50 - 100μg)或舒芬太尼(5 - 25μg)较为常用(32例中有25例),32个诊所中有12个使用硬膜外注射吗啡,大多数单位使用2mg剂量。30个单位中有20个在子宫切除术中使用鞘内注射吗啡,最常用剂量为200μg(32例中有9例)。术后监测按照国家指南进行组织;患者在术后护理病房或产科病房监测2 - 6小时,在普通外科病房监测长达12小时。呼吸抑制风险/难以监测是不使用鞘内阿片类药物的一个原因。

鞘内注射吗啡在瑞典的剖宫产和子宫切除术中广泛使用,但由于担心呼吸抑制和监测困难,在一些单位仍受到限制。

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