γ-硅基烯丙基酯的多样化反应：选择性转化为全碳季碳中心和γ-联烯二醇
Diversification reactions of γ-silyl allenyl esters: selective conversion to all-carbon quaternary centers and γ-allene dicarbinols.
作者信息
Jana Susovan, Roy Animesh, Lepore Salvatore D
机构信息
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431-0991, USA.
出版信息
Chem Commun (Camb). 2017 May 4;53(37):5125-5127. doi: 10.1039/c7cc01708a.
Abstract
The unique reactivity of γ-silyl allenyl esters is described. Taking advantage of the silyl group as a fluoride acceptor, these allenoates readily underwent addition to a variety of electrophiles to selectively yield products with all-carbon quaternary centers or allenoate dicarbinols. These dicarbinols were subsequently converted to novel highly substituted 6-hydro-2-pyrones.
摘要
描述了γ-硅基烯丙基酯的独特反应性。利用硅基作为氟化物受体，这些烯丙基酯很容易与各种亲电试剂发生加成反应，选择性地生成具有全碳季中心的产物或烯丙基酯二甲醇。这些二甲醇随后被转化为新型的高度取代的6-氢-2-吡喃酮。
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