Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Ann N Y Acad Sci. 2017 Jun;1398(1):120-129. doi: 10.1111/nyas.13350. Epub 2017 Apr 24.
Methylated flavonoids are an important type of natural flavonoid derivative with potentially multiple health benefits; among other things, they have improved bioavailability compared with flavonoid precursors. Flavonoids have been documented to have broad bioactivities, such as anticancer, immunomodulation, and antioxidant activities, that can be elevated, to a certain extent, by methylation. Understanding the structure, bioactivity, and bioavailability of methylated flavonoids, therefore, is an interesting topic with broad potential applications. Though methylated flavonoids are widely present in plants, their levels are usually low. Because developing efficient techniques to produce these chemicals would likely be beneficial, we provide an overview of their chemical and biological synthesis.
甲基化黄酮类化合物是一类重要的天然黄酮类衍生物，具有多种潜在的健康益处；与黄酮类前体相比，它们具有改善的生物利用度。黄酮类化合物具有广泛的生物活性，如抗癌、免疫调节和抗氧化活性，通过甲基化在一定程度上可以提高这些活性。因此，了解甲基化黄酮类化合物的结构、生物活性和生物利用度是一个有趣的话题，具有广泛的潜在应用。尽管甲基化黄酮类化合物广泛存在于植物中，但它们的含量通常较低。由于开发有效的生产这些化学物质的技术可能是有益的，因此我们提供了它们的化学和生物合成的概述。
