B7-H6 蛋白表达在人口腔鳞状细胞癌中的预后价值。

The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma.

机构信息

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, China.

出版信息

J Oral Pathol Med. 2017 Oct;46(9):766-772. doi: 10.1111/jop.12586. Epub 2017 Jul 28.

DOI:10.1111/jop.12586

PMID:28437013

Abstract

OBJECTIVES

To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.

MATERIALS AND METHODS

A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia (OLK) samples, and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, OLK, and normal controls was evaluated by immunohistochemical assay.

RESULTS

The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa. Furthermore, a significant relationship was found between the expression of B7-H6 and differentiation, but not with age, sex, tumor size, lymph metastasis, clinical stage, or recurrence. Further, the survival curves showed that B7-H6 was an independent prognostic factor of overall survival and disease-free survival in oral squamous cell carcinoma. Moreover, multivariate survival analysis by COX proportional hazard regression model revealed that the recurrence, differentiation, and expression of B7-H6 were related to the prognosis. Lastly, we verified the prognostic value of B7-H6 in oral squamous cell carcinoma.

CONCLUSIONS

B7-H6 may represent a new prognostic marker for oral squamous cell carcinoma.

摘要

目的

探讨 B7-H6 蛋白在口腔鳞状细胞癌组织中的表达及其预后价值。

材料与方法

分析了 50 例口腔鳞状细胞癌样本、10 例口腔白斑（OLK）样本和 17 例正常对照组织中 B7-H6 的表达情况。采用免疫组织化学法检测口腔鳞状细胞癌、OLK 和正常对照组织中 B7-H6 的表达。

结果

B7-H6 蛋白在口腔鳞状细胞癌组织中的表达明显高于正常口腔黏膜。此外，B7-H6 的表达与分化程度显著相关，与年龄、性别、肿瘤大小、淋巴转移、临床分期或复发无关。进一步的生存曲线显示，B7-H6 是口腔鳞状细胞癌总生存和无病生存的独立预后因素。此外，COX 比例风险回归模型的多因素生存分析显示，复发、分化和 B7-H6 的表达与预后有关。最后，我们验证了 B7-H6 在口腔鳞状细胞癌中的预后价值。