Fong Dominic, Spizzo Gilbert, Gostner Johanna M, Gastl Guenther, Moser Patrizia, Krammel Clemens, Gerhard Stefan, Rasse Michael, Laimer Klaus
Department of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
Mod Pathol. 2008 Feb;21(2):186-91. doi: 10.1038/modpathol.3801001. Epub 2007 Dec 14.
Squamous cell carcinoma is by far the most common type of cancer of the oral cavity, representing more than 90% of all oral cancers. Despite refinement of surgical techniques and adjuvant therapies, the prognosis for patients with oral squamous cell carcinoma remains poor. Identification of prognostic factors related to tumor biology might improve this assessment. Recently, the human trophoblast cell-surface antigen TROP2 was found to be highly expressed in colorectal cancer, correlating with aggressiveness and poor prognosis. Thus, the aim of this study was to investigate TROP2 expression and its prognostic impact in oral squamous cell carcinoma patients. TROP2 expression was examined by immunohistochemistry in a series of 90 patients on a tissue microarray of paraffin-embedded specimens. Survival was calculated using Kaplan-Meier estimates. Parameters found to be of prognostic significance in univariate analysis were verified in a multivariate Cox regression model. TROP2 overexpression was observed in 52 (58%) of the tumor samples. Kaplan-Meier curves showed that TROP2 overexpression was significantly associated with decreased overall survival (P<0.01). Overall survival gradually worsened with increasing TROP2 scores. By univariate analyses, no correlation with conventional clinicopathological features was found. Multivariate Cox regression analysis revealed TROP2 overexpression to be an independent factor predictive of poor disease outcome (P<0.01). These results demonstrate that TROP2 overexpression is an independent prognostic marker in patients with oral squamous cell carcinoma. TROP2 overexpression was detectable in 58% of the tumor samples, indicating it to be a potential novel therapeutic target in squamous cell carcinoma of the oral cavity.
鳞状细胞癌是目前口腔癌中最常见的类型，占所有口腔癌的90%以上。尽管手术技术和辅助治疗有所改进，但口腔鳞状细胞癌患者的预后仍然很差。识别与肿瘤生物学相关的预后因素可能会改善这种评估。最近，发现人类滋养层细胞表面抗原TROP2在结直肠癌中高表达，与侵袭性和不良预后相关。因此，本研究的目的是调查TROP2在口腔鳞状细胞癌患者中的表达及其预后影响。通过免疫组织化学对90例患者石蜡包埋标本的组织微阵列进行TROP2表达检测。使用Kaplan-Meier估计法计算生存率。在单变量分析中发现具有预后意义的参数在多变量Cox回归模型中得到验证。在52个（58%）肿瘤样本中观察到TROP2过表达。Kaplan-Meier曲线显示，TROP2过表达与总生存期降低显著相关（P<0.01）。总生存期随着TROP2评分的增加而逐渐恶化。单变量分析未发现与传统临床病理特征相关。多变量Cox回归分析显示，TROP2过表达是预测疾病不良结局的独立因素（P<0.01）。这些结果表明，TROP2过表达是口腔鳞状细胞癌患者的独立预后标志物。在58%的肿瘤样本中可检测到TROP2过表达，表明它是口腔鳞状细胞癌潜在的新型治疗靶点。
