J Oral Facial Pain Headache. 2017 Spring;31(2):139-146. doi: 10.11607/ofph.1728.
To assess the effect of topical application of capsaicin to the tongue as a surrogate model of burning mouth syndrome (BMS) on somatosensory sensitivity by using a standardized battery of quantitative sensory testing (QST) in healthy volunteers.
This study comprised two experimental sessions (experimental [capsaicin] and control [Vaseline]) with QST in 16 healthy women. The examiner applied capsaicin or Vaseline to the tongue tip for 5 minutes. Each participant kept their tongue tip in contact with the capsaicin/Vaseline at the bottom of a disposable cup for 5 minutes, during which time the participant rated the perceived intensity of the tongue pain every 30 seconds on an electronic 0 to 10 visual analog scale (VAS). QST was performed on the tongue tip before and immediately after application in each session. The QST data were analyzed by two-way analysis of variance (ANOVA).
Mean ± standard error of the mean (SEM) of VAS pain scores during the capsaicin and control sessions were 8.2 ± 0.5 and 1.9 ± 0.2, respectively. The peak of the perceived pain in the capsaicin session was significantly higher than in the control session (P < .001). In the capsaicin session, the postapplication heat pain threshold (HPT) was significantly higher than the preapplication HPT, and the postapplication cold detection threshold (CDT) and mechanical pain threshold (MPT) were significantly lower than before application (P < .001). The average z scores showed a significant somatosensory loss regarding CDT. In the control session, there were no differences between preapplication and postapplication values.
Topical application of capsaicin to the tongue tip changed somatosensory sensitivity in healthy participants.
通过使用标准化定量感觉测试 (QST) 对健康志愿者进行研究，评估舌部辣椒素局部应用作为灼口综合征 (BMS) 替代模型对躯体感觉敏感性的影响。
本研究包括两个实验阶段（实验[辣椒素]和对照[凡士林]），并对 16 名健康女性进行 QST。检查者将辣椒素或凡士林涂于舌前 5 分钟。每位参与者将舌前 5 分钟置于一次性杯子底部与辣椒素/凡士林接触，在此期间，参与者每 30 秒使用电子 0 到 10 视觉模拟量表 (VAS) 对舌痛感知强度进行评分。在每个阶段应用前和应用后立即对舌前进行 QST。使用双向方差分析 (ANOVA) 分析 QST 数据。
辣椒素和对照阶段的 VAS 疼痛评分平均值 ± 标准误差 (SEM) 分别为 8.2 ± 0.5 和 1.9 ± 0.2。辣椒素阶段感知疼痛的峰值明显高于对照阶段 (P <.001)。在辣椒素阶段，应用后热痛阈值 (HPT) 明显高于应用前，应用后冷觉阈值 (CDT) 和机械痛阈值 (MPT) 明显低于应用前 (P <.001)。平均 z 分数显示 CDT 存在明显的躯体感觉丧失。在对照阶段，应用前后值无差异。
舌部辣椒素局部应用改变了健康参与者的躯体感觉敏感性。
