Jørgensen Mette Rose, Pedersen Anne Marie Lynge
a Department of Odontology, Section for Oral Medicine, Clinical Oral Physiology, Oral Anatomy and Pathology, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen N , Denmark.
Acta Odontol Scand. 2017 Mar;75(2):130-136. doi: 10.1080/00016357.2016.1269191. Epub 2016 Dec 22.
To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS).
This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period.
18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p = 0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects.
Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use.
探讨重复局部应用两种不同浓度的口服辣椒素凝胶缓解灼口综合征（BMS）患者灼痛/刺痛感的有效性。
这项随机双盲交叉研究纳入了22名患有BMS的女性患者。患者被随机分为两组，分别在舌背局部应用0.01%或0.025%的口服辣椒素凝胶，每日3次，共14天，随后有14天的洗脱期，最后再用另一种浓度的口服凝胶每日3次治疗14天。在干预期内，使用视觉模拟量表（VAS）五次评估疼痛的严重程度。
18名患者完成了干预。她们在基线时的VAS评分为5.5±0.6厘米（平均值±标准差）。与基线相比，两种浓度的辣椒素凝胶治疗均显著改善了基于VAS评估的灼痛/刺痛症状（p = 0.002）。两种浓度的凝胶在缓解症状方面无统计学显著差异。4名患者在干预期内因胃肠道副作用退出。
局部应用辣椒素可能是BMS短期治疗的一种选择。然而，需要进一步研究，特别是调查可能限制其长期使用的胃肠道副作用。
