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阿曼2型糖尿病患者的心血管疾病发病率及危险因素模式:一项回顾性队列研究

Cardiovascular Disease Incidence and Risk Factor Patterns among Omanis with Type 2 Diabetes: A Retrospective Cohort Study.

作者信息

Al Rawahi Abdul Hakeem, Lee Patricia, Al Anqoudi Zaher A M, Al Busaidi Ahmed, Al Rabaani Muna, Al Mahrouqi Faisal, Al Busaidi Ahmed M

机构信息

School of Medicine, Griffith University, Queensland, Australia.

Menzies Health Institute, Queensland, Australia.

出版信息

Oman Med J. 2017 Mar;32(2):106-114. doi: 10.5001/omj.2017.20.

Abstract

OBJECTIVES

Cardiovascular disease (CVD) represents the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). Its incidence and risk factor patterns vary widely across different diabetic populations. This study aims to assess the incidence and risk factor patterns of CVD events among Omanis with T2DM.

METHODS

A sample of 2 039 patients with T2DM from a primary care setting, who were free of CVD at beseline (2009-2010) were involved in a retrospective cohort study. Socio-demographic data and traditional risk factor assessments at the baseline were retrieved from medical records, after which the first CVD outcomes (coronary heart disease, stroke, and peripheral arterial disease) were traced from the baseline to December 2015, with a median follow-up period of 5.6 years.

RESULTS

The overall cumulative incidence of CVD was 9.4% with an incidence density of 17.6 per 1000 person-years. Prevalence of poor glycemic control, hypertension, obesity, dyslipidemia, albuminuria, and current smoking were 40.0%, 56.3%, 39.0%, 77.3%, 18.7%, and 7.8%, respectively. The univariate survival analysis showed a significant association between CVD and the following factors: age, diabetes duration, body mass index, glycemic control, hypertension, total serum cholesterol, and albuminuria.

CONCLUSIONS

This study revealed high incidence of CVD and high prevalence of its traditional risk factors among Omanis with T2DM. In addition, compared to global studies, important differences in the prevalence of some risk factors and their patterns in the univariate association with the cardiovascular outcome have been observed.

摘要

目的

心血管疾病(CVD)是2型糖尿病(T2DM)患者发病和死亡的主要原因。其发病率和危险因素模式在不同的糖尿病患者群体中差异很大。本研究旨在评估阿曼T2DM患者CVD事件的发病率和危险因素模式。

方法

一项回顾性队列研究纳入了2039例来自基层医疗单位的T2DM患者,这些患者在基线时(2009 - 2010年)无CVD。从医疗记录中获取基线时的社会人口统计学数据和传统危险因素评估,之后追踪从基线到2015年12月的首次CVD结局(冠心病、中风和外周动脉疾病),中位随访期为5.6年。

结果

CVD的总体累积发病率为9.4%,发病密度为每1000人年17.6例。血糖控制不佳、高血压、肥胖、血脂异常、蛋白尿和当前吸烟的患病率分别为40.0%、56.3%、39.

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