使用大鼠模型评估褪黑素和N-乙酰半胱氨酸对麦克法兰皮瓣的影响。
Assessing the effects of melatonin and N-acetylcysteine on the McFarlane flap using a rat model.
作者信息
Tunç Süphan, Kesiktas Erol, Yilmaz Yeliz, Açikalin Arbil, Oran Gökçen, Yavuz Metin, Gencel Eyüphan, Eser Cengiz
机构信息
Department of Plastic Reconstructive and Aesthetic Surgery, Rize State Hospital, Rize, Turkey.
Department of Plastic Reconstructive and Aesthetic Surgery, Cukurova University Faculty of Medicine, Rize, Turkey.
出版信息
Plast Surg (Oakv). 2016 Fall;24(3):204-208. Epub 2016 Aug 19.
OBJECTIVE
To determine the effects of N-acetylcysteine (NAC) and melatonin, alone and in combination, on McFarlane flap viability in a rat model.
METHODS
Forty Wistar rats were divided into four groups and received daily intraperitoneal injections for one week before surgery: control (sham [n=10]); melatonin (n=10); NAC (n=10); and NAC+melatonin (n=10). One week after surgery, the experiment was terminated and photographs were taken for topographic studies. A transillumination study was performed to observe vascularization in the flaps and biopsies were obtained for histopathological studies.
RESULTS
Flap viability was significantly greater in the antioxidant- (ie, NAC and melatonin) treated groups compared with the control group; however, there were no significant differences among the groups that received antioxidants.
CONCLUSIONS
Melatonin and NAC are important antioxidants that can be used alone or in combination to increase flap viability and prevent distal necrosis in rats.
目的
在大鼠模型中确定N-乙酰半胱氨酸（NAC）和褪黑素单独及联合使用对麦克法兰皮瓣存活能力的影响。
方法
40只Wistar大鼠被分为四组，在手术前一周每天接受腹腔注射：对照组（假手术组[n = 10]）；褪黑素组（n = 10）；NAC组（n = 10）；NAC + 褪黑素组（n = 10）。手术后一周，终止实验并拍摄照片用于地形学研究。进行透照研究以观察皮瓣中的血管形成，并获取活检组织用于组织病理学研究。
结果
与对照组相比，抗氧化剂（即NAC和褪黑素）治疗组的皮瓣存活能力显著更高；然而，接受抗氧化剂的各组之间没有显著差异。
结论
褪黑素和NAC是重要的抗氧化剂，可单独或联合使用以提高大鼠皮瓣的存活能力并预防远端坏死。
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