Program in Neuroscience, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA.
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Ann Neurol. 2017 Jun;81(6):904-907. doi: 10.1002/ana.24940. Epub 2017 Jun 1.
Divergent results and misinterpretation of non-significant findings remain problematic in science – especially in retrospective, hypothesis generating, translational research. When such divergence occurs, it is imperative that the cause of the divergence be established. In their recent paper in , Dauvilliers challenged our earlier finding that cerebrospinal fluid (CSF) from some patients with unexplained excessive daytime sleepiness enhances the activation of GABA receptors (GABA-R). They present data from 15 subjects in which they were unable to find evidence of enhanced activation of GABA receptors. Here we: 1) establish how flaws in Dauvilliers’ experimental design account for this difference; 2) present new data demonstrating the robustness and reproducibility of our methods and 3) summarize the clinical promise of GABA-R antagonism in treating IH and related disorders.
在科学领域，尤其是在回顾性、产生假说、转化研究中，不一致的结果和对无显著发现的错误解读仍然是一个问题。当这种分歧发生时，确定分歧的原因至关重要。在他们最近发表在 的论文中，Dauvilliers 质疑了我们之前的发现，即一些不明原因的日间嗜睡患者的脑脊液（CSF）增强了 GABA 受体（GABA-R）的激活。他们提供了来自 15 名受试者的数据，其中他们未能发现 GABA 受体激活增强的证据。在这里，我们：1）确定了 Dauvilliers 实验设计中的缺陷如何解释这种差异；2）提出了新的数据，证明了我们方法的稳健性和可重复性；3）总结了 GABA-R 拮抗在治疗 IH 和相关疾病方面的临床前景。
