Rynders Corey A, Bergouignan Audrey, Kealey Elizabeth, Bessesen Daniel H
Division of Geriatric Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Anschutz Health & Wellness Center at the University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Obesity (Silver Spring). 2017 May;25(5):873-880. doi: 10.1002/oby.21807.
To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight.
Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28 ± 2 y; BMI: 22 ± 3 kg/m ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 years. Regression analyses examined whether changes in EE and fuel use with overfeeding predicted body weight and composition changes over 5 years.
Overfeeding increased EE and reduced fat oxidation when examined over the 24-hour, waking, and nocturnal periods. Absolute change in body mass over 5 years was 3.0 ± 0.6 kg (average rate of change = 0.7 ± 0.1 kg/y, P < 0.001). Lower nocturnal (but not 24-hour or waking) fat oxidation (r = -0.42, P = 0.01) and EE (r = -0.33, P = 0.05) with overfeeding were the strongest predictors of 5-year weight gain. When adjusted for covariates, changes in nocturnal fat oxidation and EE with overfeeding predicted 41% of the variance in weight change (P = 0.02).
Failure to maintain fat oxidation at night following a period of overfeeding appears to be associated with a metabolic phenotype favoring weight gain.
确定短期过度喂养的代谢反应是否能预测体重的纵向变化。
在一个房间热量计中，对34名瘦成年人（年龄：28±2岁；体重指数：22±3kg/m²）样本进行3天的正常热量和高热量喂养（过量40%）后，在基线时测量24小时能量消耗（EE）和底物利用情况。每年测量5年的体重和脂肪量（双能X线吸收法）。回归分析检验了过度喂养时EE和燃料使用的变化是否能预测5年内体重和身体成分的变化。
在24小时、清醒和夜间时段进行检查时，过度喂养会增加EE并减少脂肪氧化。5年内体重的绝对变化为3.0±0.6kg（平均变化率=0.7±0.1kg/年，P<0.001）。过度喂养时较低的夜间（而非24小时或清醒时）脂肪氧化（r=-0.42，P=0.01）和EE（r=-0.33，P=0.05）是5年体重增加的最强预测因素。在对协变量进行调整后，过度喂养时夜间脂肪氧化和EE的变化可预测体重变化中41%的方差（P=0.02）。
一段时间的过度喂养后夜间未能维持脂肪氧化似乎与有利于体重增加的代谢表型有关。
