Pozharisskiĭ K M, Zueva E E, Nikitin A Iu
Vopr Onkol. 1988;34(8):945-51.
An immunohistochemical investigation of chorionic gonadotropin (CGT) in normal placental, hydatidiform mole and choriocarcinoma tissues was undertaken. Cyto- and syncytiotrophoblast both were shown to produce the hormone in normal and tumor trophoblast; the rate of synthesis increased in proportion to the degree of cell elements differentiation, except for very large elements of syncytiotrophoblast with numerous pycnotic nuclei which were found to contain either only traces of response to CGT or none at all. The percentage of syncytiotrophoblast--produced hormone progressively increased in the succession of the placenta--hydatidiform mole--choriocarcinoma. No significant difference in the levels of immunohistochemically--identified hormone was found in the hydatidiform mole and choriocarcinoma.
对正常胎盘、葡萄胎和绒毛膜癌组织中的绒毛膜促性腺激素（CGT）进行了免疫组织化学研究。细胞滋养层和合体滋养层在正常和肿瘤滋养层中均显示能产生该激素；合成速率与细胞成分分化程度成比例增加，但对于含有大量固缩核的非常大的合体滋养层细胞，发现其要么仅含有微量的CGT反应，要么完全没有反应。在胎盘 - 葡萄胎 - 绒毛膜癌的序列中，合体滋养层产生的激素百分比逐渐增加。在葡萄胎和绒毛膜癌中，免疫组织化学鉴定的激素水平没有显著差异。
