a Laboratoire de virologie, hôpital Européen Georges Pompidou , Assistance Publique-Hôpitaux de Paris , France.
b Department of Immunology, INSERM U970 , Université Paris Descartes, Sorbonne Paris-Cité , Paris , France.
Expert Rev Anti Infect Ther. 2017 Jun;15(6):613-627. doi: 10.1080/14787210.2017.1322902. Epub 2017 May 5.
Infections caused by high-risk human papillomavirus (HPV) are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. This disease is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and 50,000 deaths yearly, further increased by HIV infection. Areas covered: The current status of cervical cancer associated with HPV in sub-Saharan Africa has been systematically revised. The main issues discussed here are related to the public health burden of cervical cancer in sub-Saharan Africa and predictions for the coming decades, including molecular epidemiology and determinants of HPV infection in Africa, and promising prevention measures currently being evaluated in Africa. Expert commentary: By the year 2030, cervical cancer will kill more than 443,000 women yearly worldwide, most of them in sub-Saharan Africa. The increase in the incidence of cervical cancer in Africa could counteract the progress made by African women in reducing maternal mortality and longevity. Nevertheless, cervical cancer is a potentially preventable noncommunicable disease, and intervention strategies to eliminate cervical cancer as a public health concern should be urgently implemented.
在发展中国家，由高危型人乳头瘤病毒（HPV）引起的感染占癌症的 7.7%，主要是宫颈癌。这种疾病在撒哈拉以南非洲地区呈稳步上升趋势，每年新增病例超过 7.5 万例，死亡病例超过 5 万例，且因 HIV 感染而进一步增加。
系统回顾了与撒哈拉以南非洲地区 HPV 相关的宫颈癌的现状。本文主要讨论了与撒哈拉以南非洲地区宫颈癌的公共卫生负担相关的问题，并对未来几十年进行了预测，包括非洲 HPV 感染的分子流行病学和决定因素，以及目前正在非洲评估的有前途的预防措施。
到 2030 年，全世界每年将有超过 44.3 万名妇女死于宫颈癌，其中大多数在撒哈拉以南非洲地区。非洲宫颈癌发病率的上升可能会抵消非洲妇女在降低孕产妇死亡率和延长寿命方面取得的进展。然而，宫颈癌是一种潜在可预防的非传染性疾病，消除宫颈癌这一公共卫生关注点的干预策略应紧急实施。
