Henningsson S, Hovey D, Vass K, Walum H, Sandnabba K, Santtila P, Jern P, Westberg L
Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Transl Psychiatry. 2017 Apr 25;7(4):e1102. doi: 10.1038/tp.2017.70.
Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two samples of younger and older individuals, respectively, with respect to one nonsynonymous polymorphism in the gene encoding the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in both samples had self-reported their sociosexual behavior using the sociosexual orientation inventory, including questions regarding lifetime number of one-night stands, number of partners last year and expected number of partners the coming 5 years. In women, there was a significant association between the VN1R1 polymorphism and sociosexual behavior in both samples, driven specifically by the question regarding one-night stands. Our results support the hypothesis that human social interaction is modulated by communication via chemosignaling.
信息素调节大多数哺乳动物物种的社会行为和生殖行为。这些作用由犁鼻器系统和主要嗅觉系统介导。假定信息素对人类神经内分泌活动、大脑活动和吸引力评分的影响表明，人类可能通过类似的化学信号进行交流。在此，我们分别研究了年轻个体和年长个体的两个样本，涉及编码人类犁鼻器1型受体1（VN1R1）的基因中的一个非同义多态性，以及编码嗅觉受体OR7D4的基因中的一个非同义多态性。两个样本中的参与者都使用社会性取向问卷自我报告了他们的社会性行为，问卷包括关于一生一夜情的次数、去年的性伴侣数量以及未来5年预期的性伴侣数量等问题。在女性中，两个样本中VN1R1多态性与社会性行为之间均存在显著关联，这种关联尤其由关于一夜情的问题所驱动。我们的结果支持这样的假设，即人类的社会互动是通过化学信号交流来调节的。
