Wang Yituo, Wang Lubin, Qiao Penggang, Sheng Fugeng, Han Cong, Ye Enmao, Lei Yu, Yan Feng, Chen Shanshan, Zhu Yuyang, Mi Guiyun, Li Gongjie, Yang Zheng
Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China.
Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, People's Republic of China.
PLoS One. 2017 Apr 25;12(4):e0176461. doi: 10.1371/journal.pone.0176461. eCollection 2017.
The impact of chronic cerebral hypoperfusion on resting-state blood oxygen level-dependent signal fluctuations remains unknown. We aimed to determine whether chronic ischemia induces changes in amplitude of low-frequency fluctuations (ALFF) and to investigate the correlation between ALFF and perfusion-weighted magnetic resonance imaging (PWI) parameters in patients with moyamoya disease (MMD). Thirty patients with pre- and postoperative resting-state functional magnetic resonance imaging and PWI were included, and thirty normal controls underwent resting-state functional magnetic resonance imaging. A decrease in preoperative frontal lobe ALFF was observed in patients with MMD. Postoperative frontal lobe ALFF showed moderate improvement but still remained lower than those in normal controls. The values of mean transit time and time-to-peak, but not cerebral blood volume and cerebral blood flow, correlated significantly with frontal lobe ALFF. Moreover, there were significant negative correlations between changes in frontal lobe PWI parameters and changes in frontal lobe ALFF on both operated side and contralateral side after the unilateral revascularization surgery. Our results demonstrate that reduced ALFF are closely related to the abnormal PWI parameters and vary with the alteration of cerebral perfusion in patients with MMD.
慢性脑灌注不足对静息态血氧水平依赖信号波动的影响尚不清楚。我们旨在确定慢性缺血是否会引起低频波动幅度（ALFF）的变化，并研究烟雾病（MMD）患者中ALFF与灌注加权磁共振成像（PWI）参数之间的相关性。纳入30例术前和术后均进行静息态功能磁共振成像和PWI的患者，30名正常对照者进行静息态功能磁共振成像。观察到MMD患者术前额叶ALFF降低。术后额叶ALFF有中度改善，但仍低于正常对照者。平均通过时间和达峰时间的值与额叶ALFF显著相关，而脑血容量和脑血流量则不然。此外，单侧血运重建手术后，手术侧和对侧额叶PWI参数的变化与额叶ALFF的变化之间均存在显著负相关。我们的结果表明，ALFF降低与MMD患者的异常PWI参数密切相关，并随脑灌注的改变而变化。
