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磁共振弹性成像动脉自旋标记（MR mTI-ASL）与动态磁敏感对比增强灌注加权成像（DSC-PWI）评估烟雾病患者脑血流动力学的对比研究

Comparative study of MR mTI-ASL and DSC-PWI in evaluating cerebral hemodynamics of patients with Moyamoya disease.

作者信息

Zhang Jinge, Xia Chunchao, Liu Yi, Qian Weiqiang, Peng Wanlin, Liu Keling, Li Lei, Zhao Fei, Li Zhenlin

机构信息

Department of Radiology.

Department of Neurosurgery, Sichuan University West China Hospital, Chengdu City, China.

出版信息

Medicine (Baltimore). 2018 Oct;97(41):e12768. doi: 10.1097/MD.0000000000012768.

DOI:10.1097/MD.0000000000012768
PMID:30313089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6203517/
Abstract

The aim of this study was to explore the correlation between multi-inversion time arterial spin labeling (mTI-ASL) and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) in assessment of hemodynamics of patients with Moyamoya disease (MMD).In this study, 24 MMD patients and 21 healthy subjects were enrolled between June 2017 and December 2017. The images of mTI-ASL and DSC-PWI in the week before revascularization surgery were retrospectively analyzed. The parameters of cerebral blood flow (CBF), time to peak (TTP), and bolus arrival time (BAT) were measured in regions of interest (ROIs) of lateral middle cerebral artery (MCA) territories, basal ganglia (BG), and cerebellum, and relative perfusion parameters (rCBF-ASL, rBAT-ASL, rCBF-DSC, and rTTP-DSC) were calculated by dividing by cerebellum value. One-way analysis of variance and Student-Newman-Keuls tests were performed to compare rCBF-ASL and rCBF-DSC in the MMD group and the control group. Unpaired t test was used to compare rBAT-ASL and rTTP-DSC in the MMD group and the control group. And we assessed the correlation between rCBF-ASL and rCBF-DSC and between rBAT-ASL and rTTP-DSC using Pearson correlation analysis.All the relative parameters were significantly different between the MMD group and the control group (all P<.05). Meanwhile, there was significant difference between rCBF-ASL and rCBF-DSC (P<.05), and there was strong correlation between rCBF-ASL and rCBF-DSC (r = 0.839, P<.001), and moderate correlation between rBAT-ASL and rTTP-DSC (r = 0.519, P<.001).Both mTI-ASL and DSC-PWI could be used to assess perfusion state in MMD patients before revascularization surgery effectively. As a noninvasive imaging technique, mTI-ASL could provide perfusion parameters without contrast medium injection, and the results were quite correlative with DSC-PWI.

摘要

本研究旨在探讨多反转时间动脉自旋标记（mTI-ASL）与动态磁敏感对比增强灌注加权成像（DSC-PWI）在评估烟雾病（MMD）患者血流动力学方面的相关性。本研究纳入了2017年6月至2017年12月期间的24例MMD患者和21例健康受试者。对血运重建手术前一周的mTI-ASL和DSC-PWI图像进行回顾性分析。在大脑中动脉（MCA）外侧区域、基底节（BG）和小脑的感兴趣区（ROI）测量脑血流量（CBF）、达峰时间（TTP）和团注到达时间（BAT）参数，并通过除以小脑值计算相对灌注参数（rCBF-ASL、rBAT-ASL、rCBF-DSC和rTTP-DSC）。采用单因素方差分析和Student-Newman-Keuls检验比较MMD组和对照组的rCBF-ASL和rCBF-DSC。采用非配对t检验比较MMD组和对照组的rBAT-ASL和rTTP-DSC。并采用Pearson相关分析评估rCBF-ASL与rCBF-DSC以及rBAT-ASL与rTTP-DSC之间的相关性。MMD组和对照组之间所有相对参数均有显著差异（均P<0.05）。同时，rCBF-ASL与rCBF-DSC之间存在显著差异（P<0.05），rCBF-ASL与rCBF-DSC之间存在强相关性（r = 0.839，P<0.001），rBAT-ASL与rTTP-DSC之间存在中度相关性（r = 0.519，P<0.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/1262eec098ee/medi-97-e12768-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f06a43a89aff/medi-97-e12768-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f0fd5a137256/medi-97-e12768-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f6bda08a4a34/medi-97-e12768-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/85df71991a74/medi-97-e12768-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/1262eec098ee/medi-97-e12768-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f06a43a89aff/medi-97-e12768-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f0fd5a137256/medi-97-e12768-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/f6bda08a4a34/medi-97-e12768-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/85df71991a74/medi-97-e12768-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3e/6203517/1262eec098ee/medi-97-e12768-g009.jpg

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Comparative study of MR mTI-ASL and DSC-PWI in evaluating cerebral hemodynamics of patients with Moyamoya disease.

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[3]
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引用本文的文献

[1]
Comparison of Dynamic Susceptibility Contrast and Arterial Spin Labeling MRI Perfusion in the Assessment of Stroke and Steno-Occlusive Disease: A Systematic Review and Meta-Analysis.

Diagnostics (Basel). 2025-6-21

[2]
Prediction of intracranial hemorrhage after internal carotid artery stenting in patients with symptomatic severe carotid stenosis by computed tomography perfusion.

Quant Imaging Med Surg. 2023-6-1

[3]
The value of 3D pseudo-continuousarterial spin labeling perfusion imaging in moyamoya disease-Comparison with dynamic susceptibility contrast perfusion imaging.

Front Neurosci. 2022-8-5

[4]
Caveolin-1 Promoted Collateral Vessel Formation in Patients With Moyamoya Disease.

Front Neurol. 2022-4-26

[5]
Impact of the inversion time on regional brain perfusion estimation with clinical arterial spin labeling protocols.

MAGMA. 2022-6

[6]
Comparative study of MR mTI-ASL and DSC-PWI in evaluating cerebral hemodynamics of patients with Moyamoya disease: Erratum.

Medicine (Baltimore). 2018-11

本文引用的文献

[1]
Cerebral Hemodynamic and White Matter Changes of Type 2 Diabetes Revealed by Multi-TI Arterial Spin Labeling and Double Inversion Recovery Sequence.

Front Neurol. 2017-12-22

[2]
Clinical assessment of cerebral hemodynamics in Moyamoya disease via multiple inversion time arterial spin labeling and dynamic susceptibility contrast-magnetic resonance imaging: A comparative study.

J Neuroradiol. 2017-7

[3]
Arterial Transit Time Mapping Obtained by Pulsed Continuous 3D ASL Imaging with Multiple Post-Label Delay Acquisitions: Comparative Study with PET-CBF in Patients with Chronic Occlusive Cerebrovascular Disease.

PLoS One. 2016-6-8

[4]
Prolonged Mean Transit Time Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Predicts Cerebrovascular Reserve Impairment in Patients with Moyamoya Disease.

Cerebrovasc Dis. 2016

[5]
Comparative study of DSC-PWI and 3D-ASL in ischemic stroke patients.

J Huazhong Univ Sci Technolog Med Sci. 2015-12

[6]
Moyamoya disease and syndromes: from genetics to clinical management.

Appl Clin Genet. 2015-2-16

[7]
Improvement of image quality and radiation dose of CT perfusion of the brain by means of low-tube voltage (70 KV).

Eur Radiol. 2014-8

[8]
Practical clinical use of dynamic susceptibility contrast magnetic resonance imaging for the surgical treatment of moyamoya disease.

Neurosurgery. 2014-3

[9]
Arterial spin labeling magnetic resonance perfusion imaging in cerebral ischemia.

Curr Opin Neurol. 2014-2

[10]
Arterial spin-labeling MR imaging in Moyamoya disease compared with clinical assessments and other MR imaging findings.

Eur J Radiol. 2013-9-1

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