Ebina Yasuhiko, Nishino Yukari, Deguchi Masashi, Maesawa Yoko, Nakashima Yuki, Yamada Hideto
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho Chuo-ku, Kobe 650-0017, Japan.
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho Chuo-ku, Kobe 650-0017, Japan.
J Reprod Immunol. 2017 Apr;120:42-47. doi: 10.1016/j.jri.2017.04.005. Epub 2017 Apr 13.
This study aimed to evaluate whether natural killer (NK) cell activity was associated with the etiology of recurrent miscarriage (RM), and to evaluate the predictive value of NK cell activity for outcomes of following pregnancies in women with RM. Peripheral NK cell activity was measured in 160 non-pregnant women with a history of two or more miscarriages. This activity was compared according to the etiology of RM and to pregnancy outcomes in women who became pregnant. NK cell activity in women with unexplained RM was significantly higher than that in those with known etiologies of RM. NK cell activity in women whose next pregnancies ended in miscarriage of fetuses with a normal chromosome karyotype (MN) was higher than that in those with live births (p<0.05). Women with NK cell activity ≥33% had a higher risk for MN (relative risk 3.4, 95% confidence interval 1.3-8.7). An increase in peripheral NK cell activity was associated with MN. This increase might be involved in the pathophysiology underlying RM.
本研究旨在评估自然杀伤（NK）细胞活性是否与复发性流产（RM）的病因相关，并评估NK细胞活性对RM女性后续妊娠结局的预测价值。对160名有两次或更多次流产史的非妊娠女性测量外周血NK细胞活性。根据RM的病因以及妊娠女性的妊娠结局对该活性进行比较。不明原因RM女性的NK细胞活性显著高于有已知RM病因的女性。下次妊娠以染色体核型正常胎儿流产（MN）告终的女性的NK细胞活性高于分娩活婴的女性（p<0.05）。NK细胞活性≥33%的女性发生MN的风险更高（相对风险3.4，95%置信区间1.3 - 8.7）。外周血NK细胞活性增加与MN相关。这种增加可能参与了RM潜在的病理生理学过程。
