Wang S F, Zhang L, Li G H, Zhang W W, Wang Y P, Geng B
Health Management Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010070, China.
Department of Otorhinolaryngology, Inner Mongolia Medical University Affiliated Hospital, Hohhot 010050, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Apr 7;52(4):287-290. doi: 10.3760/cma.j.issn.1673-0860.2017.04.010.
The estrogen level and blood calcium concentration changes were studied on menopausal women with benign paroxysmal positional vertigo (BPPV). Between January 2015 and January 2016, 70 menopause women with BPPV in outpatient clinics of Department of Otorhinolaryngology, Inner Mongolia Medical University Affiliated Hospital were included in this study as research group, while 30 menopause healthy women who came to hospital for check-up were included as control group. Serum levels of estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (PRO), testosterone (T), serum prolactin (PRL) and the calcium concentration were analysed and comparied between research group and control group. SPSS17.0 statistical software was used to analyze the data. χ(2) test was used to compare the percentage of decreased serum level of sex hormone, and test was used to compare the serum level of sex hormone and calcium concentration of two groups. In research group, sex hormone decreased proportion of E2 (91%) and PRO (67%) were obviously higher than those in control group (χ(2) value was 8.13, 10.28, respectively, all <0.05). The E2 and PRO in research group were significantly lower than those in control group ((33.18±31.45) pmol/L (64.92 ±31.52) pmol/L, (0.64±0.48) nmol/L (1.02±0.60) nmol/L, value was 6.238, 8.566, respectively, all <0.05). There was no statistically significant difference of the level of LH, PRL, T, FSH and blood calcium concentration in research group compared with control group ((29.81±13.13) U/L (27.21±10.19) U/L, (0.49±0.20) nmol/L (0.49±0.15) nmol/L, (0.56±0.42) nmol/L (0.73±0.62) nmol/L, (64.25±31.44) U/L (60.38±29.97) U/L, (2.28±0.17) mmol/L (2.32±0.21) mmol/L, value was 13.427, 14.876, 7.505, 12.090, 7.532, respectively, all >0.05). The level of E2 and PRO decrease obviously in postmenopausal women with BPPV, which can cause the inner ear microcirculation disorder , may be one of the risk factors of BPPV.
对患有良性阵发性位置性眩晕（BPPV）的绝经女性的雌激素水平和血钙浓度变化进行了研究。2015年1月至2016年1月，内蒙古医科大学附属医院耳鼻喉科门诊的70例患有BPPV的绝经女性被纳入本研究作为研究组，同时将30例前来医院体检的绝经健康女性作为对照组。分析并比较了研究组和对照组的血清雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）、孕酮（PRO）、睾酮（T）、血清催乳素（PRL）水平及血钙浓度。采用SPSS17.0统计软件进行数据分析。采用χ(2)检验比较性激素水平降低的百分比，采用t检验比较两组的性激素水平和血钙浓度。研究组中，E2（91%）和PRO（67%）降低的比例明显高于对照组（χ(2)值分别为8.13、10.28，均<0.05）。研究组的E2和PRO明显低于对照组（(33.18±31.45) pmol/L比(64.92 ±31.52) pmol/L，(0.64±0.48) nmol/L比(1.02±0.60) nmol/L，t值分别为6.238、8.566，均<0.05）。与对照组相比，研究组的LH、PRL、T、FSH水平及血钙浓度差异无统计学意义（(29.81±13.13) U/L比(27.21±10.19) U/L，(0.49±0.20) nmol/L比(0.49±0.15) nmol/L，(0.56±0.42) nmol/L比(0.73±0.62) nmol/L，(64.25±31.44) U/L比(60.38±29.97) U/L，(2.28±0.17) mmol/L比(2.32±0.21) mmol/L，t值分别为13.427、14.876、7.505、12.090、7.532，均>0.05）。患有BPPV的绝经后女性E2和PRO水平明显降低，这可能导致内耳微循环障碍，可能是BPPV的危险因素之一。
