Mind the magnesium, in dantrolene suppression of malignant hyperthermia.
作者信息
Cannon Stephen C
机构信息
Department of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095
出版信息
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4576-4578. doi: 10.1073/pnas.1704103114. Epub 2017 Apr 25.
Abstract
摘要
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Mind the magnesium, in dantrolene suppression of malignant hyperthermia.注意镁元素在丹曲林抑制恶性高热中的作用。
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4576-4578. doi: 10.1073/pnas.1704103114. Epub 2017 Apr 25.
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Dantrolene requires Mg to arrest malignant hyperthermia.丹曲林需要镁来阻止恶性高热。
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4811-4815. doi: 10.1073/pnas.1619835114. Epub 2017 Apr 3.
2
Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.使用“核上”膜片钳技术对1型兰尼碱受体单通道活性进行表征。
Cell Calcium. 2014 Aug;56(2):96-107. doi: 10.1016/j.ceca.2014.05.004. Epub 2014 Jun 6.
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Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP.氟烷对骨骼肌兰尼碱受体的调节作用：对Ca2+、Mg2+和ATP的依赖性
Am J Physiol Cell Physiol. 2008 Apr;294(4):C1103-12. doi: 10.1152/ajpcell.90642.2007. Epub 2008 Feb 27.
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Defective Mg2+ regulation of RyR1 as a causal factor in malignant hyperthermia.兰尼碱受体1（RyR1）的Mg2+调节缺陷作为恶性高热的一个致病因素。
Arch Biochem Biophys. 2007 Feb 1;458(1):57-64. doi: 10.1016/j.abb.2006.03.001. Epub 2006 Mar 20.
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Malignant hyperthermia: update on susceptibility testing.恶性高热：易感性检测的最新进展
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Anaesthetic deaths in a family.家族中的麻醉死亡病例
Br J Anaesth. 1962 Jun;34:395-6. doi: 10.1093/bja/34.6.395.
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Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor.骨骼肌兰尼碱受体上丹曲林结合序列的鉴定。
J Biol Chem. 2002 Sep 20;277(38):34918-23. doi: 10.1074/jbc.M205487200. Epub 2002 Jul 11.
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Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers.丹曲林对哺乳动物骨骼肌纤维兴奋-收缩偶联步骤的影响。
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Am J Med. 1998 May;104(5):470-86. doi: 10.1016/s0002-9343(98)00108-9.
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