Larue-Achagiotis C, Le Magnen J
Pharmacol Biochem Behav. 1978 Dec;9(6):717-20. doi: 10.1016/0091-3057(78)90345-3.
In order to clarify the role of endogenous insulin in generating normal and pathological feeding behaviors, the effect of an anti-insulin drug, Diazoxide, on the meal pattern has been investigated in both normal and VMH rats. A dose-dependent reduction of food intake under Diazoxide treatment was found in normal rats. The same percentage reduction was obtained at night with a higher dose than required in the daytime. Conversely, hyperphagic VMH rats exhibited a dose-dependent reduction which was identical in the two portions of the diurnal cycle. The dose effective in entirely suppressing eating in VMH rats was twice that required for normal rats in the daytime period and identical at night. The results are discussed in relation to earlier findings concerning the diurnal insulino-secretory pattern in normal and VMH rats.
为了阐明内源性胰岛素在产生正常和病理性摄食行为中的作用，研究了抗胰岛素药物二氮嗪对正常大鼠和腹内侧下丘脑（VMH）大鼠进食模式的影响。在二氮嗪治疗下，正常大鼠的食物摄入量呈剂量依赖性减少。夜间以高于白天所需的剂量可获得相同百分比的减少。相反，食欲亢进的VMH大鼠表现出剂量依赖性减少，在昼夜周期的两个时间段内是相同的。完全抑制VMH大鼠进食的有效剂量是白天正常大鼠所需剂量的两倍，夜间相同。结合先前关于正常大鼠和VMH大鼠昼夜胰岛素分泌模式的研究结果对这些结果进行了讨论。
