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厄洛替尼导致生长期毛发松动固定及扭曲发

Loose Anchoring of Anagen Hairs and Pili Torti due to Erlotinib.

作者信息

Pirmez Rodrigo, Piñeiro-Maceira Juan, Gonzalez Carmen Gloria, Miteva Mariya

机构信息

Department of Dermatology, Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil.

Department of Dermatology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Int J Trichology. 2016 Oct-Dec;8(4):186-187. doi: 10.4103/ijt.ijt_16_16.

DOI:10.4103/ijt.ijt_16_16
PMID:28442878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5387882/
Abstract

Erlotinib is a selective epidermal growth factor receptor inhibitor utilized in the treatment of solid tumors. Cutaneous side effects, including changes in hair texture and alopecia, have been described. In this case report, we describe two patients with a new finding of loose anagen hairs and pili torti leading to nonscarring marginal and diffuse alopecia and discuss potential mechanisms underlying erlotinib-induced hair changes.

摘要

厄洛替尼是一种用于治疗实体瘤的选择性表皮生长因子受体抑制剂。已经有关于其皮肤副作用的报道，包括头发质地改变和脱发。在本病例报告中，我们描述了两名出现新发现的生长期毛发松动和扭曲发，导致非瘢痕性边缘性和弥漫性脱发的患者，并讨论了厄洛替尼引起头发改变的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8d/5387882/8807c948785f/IJT-8-186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8d/5387882/aff500c73422/IJT-8-186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8d/5387882/8807c948785f/IJT-8-186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8d/5387882/aff500c73422/IJT-8-186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8d/5387882/8807c948785f/IJT-8-186-g002.jpg

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