俄罗斯中部和西伯利亚急性冠状动脉综合征患者的多态性频率。

polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome.

作者信息

Mirzaev Karin B, Zelenskaya Elena M, Barbarash Olga L, Ganyukov Vladimir I, Apartsin Konstantin A, Saraeva Natalya O, Nikolaev Konstantin Y, Ryzhikova Kristina A, Lifshits Galina I, Sychev Dmitry A

机构信息

Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow.

Federal State-Financed Research Institution "Institute of Chemical Biology and Fundamental Medicine", Siberian Branch of the Russian Academy of Sciences, Novosibirsk.

出版信息

Pharmgenomics Pers Med. 2017 Apr 12;10:107-114. doi: 10.2147/PGPM.S126305. eCollection 2017.

DOI:10.2147/PGPM.S126305

PMID:28442925

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5397026/

Abstract

PURPOSE

The aim of this study is to investigate the frequency of allelic variants, associated with poor response to clopidogrel, and , associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia.

PATIENTS AND METHODS

The study included 512 ACS patients who were subsequently treated with coronary arterial stenting. The subjects assigned were from the cities of Central (Novosibirsk, Kemerovo), Eastern (Irkutsk), Northern (Surgut) Siberia regions and from Moscow region. The mean age of patients enrolled was 63.9±10.9 years. Among the assigned subjects, the proportion of men accounted for 80% and women 20%.

RESULTS

According to the results obtained in the present study, from 16% up to 27.5% of patients in different regions of Russia have at least one "poor metabolizer" (PM) allele variant affecting clopidogrel metabolism and, therefore, suppressing its antiplatelet activity. allele variant was identified with the frequency of 15.4% up to 33.3%. The study revealed the presence of statistically significant differences in allele frequency between the Russian ethnic group patients from Eastern and Central Siberia (=0.001; odds ratio=1.05 [95% confidence interval 1.01-1.09]).

CONCLUSION

The study revealed statistically significant differences between the allele frequencies in Eastern and Central Siberia, which can probably be caused by a considerable number of Buryats inhabiting Eastern Siberia.

摘要

目的

本研究旨在调查俄罗斯西伯利亚和莫斯科地区急性冠状动脉综合征（ACS）患者中与氯吡格雷反应不佳相关以及与氯吡格雷反应过度相关的等位基因变体的频率。

患者与方法

该研究纳入了512例随后接受冠状动脉支架置入治疗的ACS患者。指定的受试者来自西伯利亚中部（新西伯利亚、克麦罗沃）、东部（伊尔库茨克）、北部（苏尔古特）地区的城市以及莫斯科地区。入选患者的平均年龄为63.9±10.9岁。在指定的受试者中，男性占80%，女性占20%。

结果

根据本研究获得的结果，俄罗斯不同地区16%至27.5%的患者至少有一个影响氯吡格雷代谢并因此抑制其抗血小板活性的“代谢缓慢者”（PM）等位基因变体。等位基因变体的识别频率为15.4%至33.3%。该研究揭示了来自东西伯利亚的俄罗斯族患者之间等位基因频率存在统计学显著差异（P=0.001；优势比=1.05[95%置信区间1.01 - 1.09]）。