Bekusova Viktoria V, Patsanovskii Vasily M, Nozdrachev Alexander D, Trashkov Alexandr P, Artemenko Margarita R, Anisimov Vladimir N
Department of Physiology, St. Petersburg State University, St. Petersburg 197183, Russia.
I.P.Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg 199034, Russia.
Cancer Biol Med. 2017 Feb;14(1):100-107. doi: 10.20892/j.issn.2095-3941.2016.0088.
Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.
研究了两剂抗糖尿病药物二甲双胍（MF）对1,2-二甲基肼（DMH）诱导的非糖尿病雄性Wistar大鼠结肠肿瘤腺癌血清激素和代谢水平的影响。还观察了动物的致癌作用。DMH诱导的结肠腺癌大鼠的血清葡萄糖、胰岛素、胰岛素样生长因子-1、总胆固醇、甘油三酯、过氧化氢酶、丙二醛、糖化血红蛋白、天冬氨酸转氨酶和丙氨酸转氨酶水平升高，血红蛋白降低。两剂MF治疗使DMH处理大鼠的这些变化大部分恢复正常，而该药物对未接受DMH治疗的大鼠无效。唯一的例外是MF治疗大鼠的甘油三酯水平降低。与未治疗的大鼠相比，100 mg/kg剂量的MF增加了DMH诱导的外生性结肠癌并减少了内生性肿瘤。此外，与给予DMH和水的大鼠相比，两种MF剂量均增加了DMH诱导的高分化肿瘤并降低了结肠癌的侵袭性。因此，MF对代谢稳态的影响对于预防结肠癌至关重要。
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