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[Partial purification of endogenous inhibitors of (+)-[3H] SKF 10047 binding with sigma-opioid receptors of the liver].

作者信息

Nagornaia L V, Samovilova N N, Korobov N V, Vinogradov V A

出版信息

Biull Eksp Biol Med. 1988 Sep;106(9):314-7.

PMID:2844323
Abstract

Porcine liver extract inhibits (+)-[3H]SKF 10047 binding to rat liver membranes. The inhibitors of (+)-[3H]SKF 10047 binding were detected in acetone supernatant and in acid acetonated powder of the liver extract. Partial purification of the acetone supernatant revealed some characteristics of these inhibitors: low molecular weight (less than 1000), thermostability, resistance to pronase digestion, solubility in water and organic solvents.

摘要

相似文献

1
[Partial purification of endogenous inhibitors of (+)-[3H] SKF 10047 binding with sigma-opioid receptors of the liver].
Biull Eksp Biol Med. 1988 Sep;106(9):314-7.
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An endogenous ligand for the sigma opioid binding site.
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Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.用（+）-[³H]SKF 10,047、（+）-[³H]-3-[3-羟基苯基]-N-（1-丙基）哌啶和[³H]-1-[1-（2-噻吩基）环己基]哌啶对脑中σ和苯环利定受体结合位点进行药理学和放射自显影鉴别。
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Heterogeneous binding of sigma radioligands in the rat brain and liver: possible relationship to subforms of cytochrome P-450.
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Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes.
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J Pharmacol Exp Ther. 1982 Nov;223(2):284-90.

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