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睾丸畸胎瘤伴腹膜后转移中发生的原始神经外胚层肿瘤:病例报告及文献复习

Primitive Neuro Ectodermal Tumor Arising in a Testicular Teratoma with Retroperitoneal Metastasis: A Case Report and Review of Literature.

作者信息

Hu Guodong, Wang Andrew, Wang Xiu, Xia Leilei, Taylor Benjamin L, Malkowicz S Buce, Lal Priti, Maisel Julia R

机构信息

The Second Department of Urology, Shenyang Red Cross Hospital, Shenyang, LN, China.

Department of Urology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

出版信息

Urol Case Rep. 2017 Apr 19;13:39-41. doi: 10.1016/j.eucr.2016.11.025. eCollection 2017 Jul.

DOI:10.1016/j.eucr.2016.11.025
PMID:28443239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5397596/
Abstract

A 38-year-old man presenting with left testicular mass and extensive retroperitoneal lymphadenopathy underwent radical orchiectomy and specimen showed a germ cell tumor of primarily primitive neuroectodermal tumor mixed with mature teratoma. He then underwent RPLND, followed by adjuvant CAV (cyclophosphamide, doxorubicin, vincristine) and IE (ifosfamide, etoposide) alternating chemotherapy given the high rate of recurrence and high rate of response to the PNET-specific chemotherapy.

摘要

一名38岁男性,因左侧睾丸肿物及广泛腹膜后淋巴结肿大接受了根治性睾丸切除术,标本显示为主要为原始神经外胚层肿瘤并伴有成熟畸胎瘤的生殖细胞肿瘤。鉴于复发率高以及对PNET特异性化疗的高反应率,他随后接受了腹膜后淋巴结清扫术,接着进行了辅助性CAV(环磷酰胺、阿霉素、长春新碱)和IE(异环磷酰胺、依托泊苷)交替化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/14bc096ca2e0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/189df725d2ee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/3e1b90aa6a34/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/14bc096ca2e0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/189df725d2ee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/3e1b90aa6a34/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b4/5397596/14bc096ca2e0/gr3.jpg

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本文引用的文献

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A case series of transformation of teratoma to primitive neuroectodermal tumor: evolving management of a rare malignancy.畸胎瘤转化为原始神经外胚层肿瘤的病例系列:一种罕见恶性肿瘤的治疗进展
Rare Tumors. 2014 Mar 18;6(1):5268. doi: 10.4081/rt.2014.5268. eCollection 2014 Jan 23.
2
Metastatic malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): results with PNET-based chemotherapy.畸胎瘤向原始神经外胚层肿瘤(PNET)的转移性恶性转化:基于PNET的化疗结果。
Am J Clin Oncol. 2015 Aug;38(4):364-6. doi: 10.1097/COC.0b013e31829d1ed7.
3
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Eur J Case Rep Intern Med. 2020 Apr 7;7(8):001439. doi: 10.12890/2020_001439. eCollection 2020.
性腺生殖细胞肿瘤:一篇选择性综述,重点强调鉴别诊断中的问题、新认识的问题及有争议的问题。
Mod Pathol. 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310.
4
Germ cell tumor associated primitive neuroectodermal tumors.生殖细胞肿瘤相关的原始神经外胚层肿瘤
J Urol. 2001 May;165(5):1514-6.