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Metastatic basal cell carcinoma with loss of p63 and mismatch repair proteins.

作者信息

Johnson Nathan M, Holliday Alex C, Luyimbazi David T, Phillips Mariana A, Collins George R, Grider Douglas J

机构信息

Virginia Tech Carilion School of Medicine, Roanoke, Virginia.

Department of Internal Medicine, Dermatology Section, Carilion Clinic and Virginia Tech Carilion School of Medicine; Roanoke, Virginia.

出版信息

JAAD Case Rep. 2017 Apr 14;3(3):222-224. doi: 10.1016/j.jdcr.2017.02.018. eCollection 2017 May.

DOI:10.1016/j.jdcr.2017.02.018
PMID:28443315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5394203/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/d992115f9d99/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/9d5b8e94e2ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/4e728916d050/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/48b12c23461d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/d992115f9d99/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/9d5b8e94e2ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/4e728916d050/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/48b12c23461d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c80f/5394203/d992115f9d99/gr4.jpg

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Can J Ophthalmol. 2014 Aug;49(4):326-32. doi: 10.1016/j.jcjo.2014.04.004. Epub 2014 Jul 19.
2
Metastatic basal cell carcinoma: prognosis dependent on anatomic site and spread of disease.转移性基底细胞癌：预后取决于发病部位和疾病的扩散情况。
Eur J Cancer. 2014 Mar;50(4):774-83. doi: 10.1016/j.ejca.2013.12.013. Epub 2014 Jan 9.
3
Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.
TP63 和 SHH 通路之间的相互作用是表皮稳态的一个重要决定因素。
Cell Death Differ. 2013 Aug;20(8):1080-8. doi: 10.1038/cdd.2013.41. Epub 2013 May 17.
4
Defects in DNA mismatch repair do not account for early-onset basal cell carcinoma.DNA错配修复缺陷并不能解释早发性基底细胞癌的发生。
Br J Dermatol. 2008 Sep;159(3):751-3. doi: 10.1111/j.1365-2133.2008.08721.x. Epub 2008 Jul 4.
5
Evidence that dysregulated DNA mismatch repair characterizes human nonmelanoma skin cancer.DNA错配修复失调是人类非黑色素瘤皮肤癌特征的证据。
Br J Dermatol. 2008 Jan;158(1):59-69. doi: 10.1111/j.1365-2133.2007.08249.x. Epub 2007 Oct 26.
6
Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis.p63缺失导致细胞迁移增加以及参与侵袭和转移的基因上调。
Cancer Res. 2006 Aug 1;66(15):7589-97. doi: 10.1158/0008-5472.CAN-06-2020.
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