Chappell M E, Keeling D M, Prentice H G, Sweny P
Department of Histopathology, Royal Free Hospital, London, UK.
Bone Marrow Transplant. 1988 Jul;3(4):339-47.
Eight cases of haemolytic uraemic syndrome occurring after bone marrow transplantation are presented and the other 15 reported cases are reviewed. Two patients were recipients of autologous marrow whereas all cases previously reported occurred after allogeneic transplantation. Six patients had not received cyclosporin and two had no evidence of cytomegalovirus infection. The roles of cyclosporin, cytomegalovirus infection, graft-versus-host disease, total body irradiation (TBI) and chemotherapeutic drugs as aetiological agents are discussed. It is postulated that TBI, perhaps potentiated by cyclophosphamide, is likely to be the most important factor but that other agents may act additively with TBI and influence the time course and severity of the disease.
本文报告了8例骨髓移植后发生的溶血性尿毒症综合征病例，并对其他15例已报道的病例进行了回顾。2例患者接受了自体骨髓移植，而此前报道的所有病例均发生在异体移植后。6例患者未接受环孢素治疗，2例没有巨细胞病毒感染的证据。文中讨论了环孢素、巨细胞病毒感染、移植物抗宿主病、全身照射（TBI）和化疗药物作为病因的作用。据推测，TBI可能在环磷酰胺的作用下增强，很可能是最重要的因素，但其他因素可能与TBI起相加作用，并影响疾病的病程和严重程度。
