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神经肽Y并不抑制大鼠腺垂体中间部α-促黑素细胞激素的释放。

Neuropeptide Y does not inhibit the release of alpha-MSH from the pars intermedia of the rat adenohypophysis.

作者信息

Kraicer J, Lussier B, Kotanen S, Moor B C

机构信息

Department of Physiology, University of Western Ontario, London, Canada.

出版信息

Can J Physiol Pharmacol. 1988 Apr;66(4):318-20. doi: 10.1139/y88-054.

DOI:10.1139/y88-054
PMID:2844369
Abstract

Neuropeptide Y in concentrations from 10(-8) to 10(-6) M inhibits the release of alpha-MSH from the frog (Rana pipiens) pituitary in a reversible, sustained, and concentration-related manner. However, it does not inhibit the release of alpha-MSH from the rat pars intermedia. Thus, while neuropeptide Y may play a role in the control of alpha-MSH release in amphibia, it appears not to be a regulatory peptide for the mammalian pars intermedia.

摘要

浓度为10⁻⁸至10⁻⁶M的神经肽Y以可逆、持续且与浓度相关的方式抑制青蛙(豹蛙)垂体中α-促黑素(α-MSH)的释放。然而,它并不抑制大鼠中间部中α-MSH的释放。因此,虽然神经肽Y可能在两栖动物α-MSH释放的控制中发挥作用,但它似乎不是哺乳动物中间部的调节肽。

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Can J Physiol Pharmacol. 1988 Apr;66(4):318-20. doi: 10.1139/y88-054.
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引用本文的文献

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Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents.黑素抑制素(神经肽Y)通过调节钾离子、钠离子和钙离子电流来抑制青蛙黑素细胞刺激素细胞的电活动。
J Physiol. 1994 Mar 1;475(2):185-95. doi: 10.1113/jphysiol.1994.sp020060.