Beltran Anzola Any, Pauly Vanessa, Montjean Debbie, Meddeb Line, Geoffroy-Siraudin Cendrine, Sambuc Roland, Boyer Pierre, Gervoise-Boyer Marie-José
Département de Santé Publique et Maladies Chroniques, Unité de recherche EA 3279, Faculté de médecine, Aix-Marseille Université, 27 Boulevard Jean Moulin, 13005, Marseille, France.
Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 26 Boulevard du Louvain, 13008, Marseille, France.
J Assist Reprod Genet. 2017 Jul;34(7):867-876. doi: 10.1007/s10815-017-0903-9. Epub 2017 Mar 23.
A retrospective cohort study was conducted to evaluate and compare the prevalence of congenital anomalies in babies and fetuses conceived after four procedures of assisted reproduction technologies (ART).
The prevalence of congenital anomalies was compared retrospectively between 2750 babies and fetuses conceived between 2001 and 2014 in vitro fertilization with standard insemination (IVF), IVF with intracytoplasmic sperm injection (ICSI), IVF with frozen embryo transfer (FET-IVF), and ICSI with frozen embryo transfer (FET-ICSI). Congenital anomalies were described according to European Surveillance of Congenital Anomalies (EUROCAT) classification. The parental backgrounds, biologic parameters, obstetric parameters, and perinatal outcomes were compared between babies and fetuses with and without congenital anomalies. Data were analyzed by the generalized estimating equation.
Between 2001 and 2014, a total of 2477 evolutionary pregnancies were notified. Among these pregnancies, 2379 were included in the analysis. One hundred thirty-four babies and fetuses had a congenital anomaly (4.9%). The major prevalences found among the recorded anomalies were congenital heart defects, chromosomal anomalies, and urinary defects. However, the risk of congenital anomalies in babies and fetuses conceived after FET was not increased compared with babies and fetuses conceived after fresh embryo transfer, even when adjusted for confounding factors (p = 0.40).
There is no increased risk of congenital anomalies in babies and fetuses conceived by fresh versus frozen embryo transfer after in vitro fertilization with and without micromanipulation. Indeed, distribution of congenital anomalies found in our population is consistent with the high prevalence of congenital heart defects, chromosomal anomalies, and urinary defects that have been found by other authors in children conceived by infertile couples when compared to children conceived spontaneously.
进行一项回顾性队列研究，以评估和比较四种辅助生殖技术（ART）后受孕的婴儿和胎儿先天性异常的患病率。
回顾性比较2001年至2014年间通过标准授精体外受精（IVF）、卵胞浆内单精子注射体外受精（ICSI）、冻融胚胎移植体外受精（FET-IVF）和冻融胚胎移植卵胞浆内单精子注射（FET-ICSI）受孕的2750例婴儿和胎儿先天性异常的患病率。根据欧洲先天性异常监测（EUROCAT）分类描述先天性异常。比较有和没有先天性异常的婴儿和胎儿的父母背景、生物学参数、产科参数和围产期结局。采用广义估计方程分析数据。
2001年至2014年间，共报告了2477例进展性妊娠。在这些妊娠中，2379例纳入分析。134例婴儿和胎儿有先天性异常（4.9%）。记录的异常中主要的患病率是先天性心脏缺陷、染色体异常和泌尿系统缺陷。然而，即使在调整混杂因素后，FET后受孕的婴儿和胎儿先天性异常的风险与新鲜胚胎移植后受孕的婴儿和胎儿相比没有增加（p = 0.40）。
体外受精有或没有显微操作后，新鲜胚胎移植与冻融胚胎移植受孕的婴儿和胎儿先天性异常风险没有增加。事实上，与自然受孕儿童相比，我们人群中发现的先天性异常分布与其他作者在不育夫妇受孕儿童中发现的先天性心脏缺陷、染色体异常和泌尿系统缺陷的高患病率一致。
