Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.

Five cases of granular cell tumor of the esophagus are reported. In four cases, the tumor was an asymptomatic, incidental finding. In one case, a larger granular cell tumor presented with dysphagia and required local surgical excision. Long-term follow-up in three cases revealed no evidence of tumor progression. Esophageal granular cell tumors are benign lesions which can frequently be diagnosed by endoscopic biopsy. Asymptomatic, smaller lesions require observation only. Larger, symptomatic lesions can be treated with local surgical excision.