DeLorenzo R J
Department of Neurology, Virginia Commonwealth Universtiy, Medical College of Virginia, Richmond 23298.
Epilepsia. 1988;29 Suppl 2:S35-47. doi: 10.1111/j.1528-1157.1988.tb05796.x.
Understanding the mechanisms of action of anticonvulsant drugs has been a major research effort of neuroscientists for the last three decades. Numerous biochemical and electrophysiological processes have been shown to be modulated by anticonvulsant drugs. However, clear correlations of these effects with anticonvulsant activity are often difficult to determine. Over the last 5 years, several major research areas have developed that shed new light on the mechanisms of action of anticonvulsant drugs. Although a complete discussion of all aspects of anticonvulsant research are not possible in the scope of this article, a description of benzodiazepine receptors, mechanisms involved in neuronal sustaining repetitive firing, and calcium regulation of neuronal function have direct bearing on neuronal excitability and ultimately on anticonvulsant drug effect. Each of these major research areas has opened new insights into our understanding of molecular mechanisms of how anticonvulsant drugs work.
在过去三十年里，了解抗惊厥药物的作用机制一直是神经科学家的一项主要研究工作。大量的生化和电生理过程已被证明会受到抗惊厥药物的调节。然而，这些效应与抗惊厥活性之间的明确关联往往很难确定。在过去五年中，出现了几个重要的研究领域，为抗惊厥药物的作用机制提供了新的线索。尽管在本文范围内不可能全面讨论抗惊厥研究的所有方面，但对苯二氮䓬受体、神经元维持重复放电所涉及的机制以及神经元功能的钙调节的描述，与神经元兴奋性以及最终与抗惊厥药物的效果直接相关。这些主要研究领域中的每一个都为我们理解抗惊厥药物的作用分子机制带来了新的见解。
