HIV-1 聚糖盾牌：盔甲上巧妙的转折提高了抗原设计。
The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design.
机构信息
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
出版信息
Cell Rep. 2017 Apr 25;19(4):669-670. doi: 10.1016/j.celrep.2017.04.033.
PMID:28445718
Abstract
Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.
摘要
HIV-1 包膜糖蛋白上密集的糖基化会阻碍针对 HIV-1 的广泛中和抗体的产生。Zhou 等人去除关键糖基以揭示易损位点，从而能够诱导中和抗体。
Zotero 插件