Fagerberg Björn, Borné Yan, Sallsten Gerd, Smith J Gustav, Acosta Stefan, Persson Margaretha, Melander Olle, Forsgard Niklas, Gottsäter Anders, Hedblad Bo, Barregard Lars, Engström Gunnar
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Department of Clinical Sciences, Malmö, Lund University, SE-221 00 Lund, Sweden.
Atherosclerosis. 2017 Jun;261:37-43. doi: 10.1016/j.atherosclerosis.2017.04.007. Epub 2017 Apr 8.
Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk of abdominal aortic aneurysm (AAA).
All middle-aged men and women enrolled in the Malmö Diet and Cancer study (n = 30 447) were followed from the baseline examination in 1991-1996 through 2009. A total of 297 cases with AAA and two randomly selected control subjects for each case, matched for age and sex, were included. Blood Cd was analysed by inductively coupled plasma mass spectrometry. Diagnoses of AAA, thoracic aortic aneurysm and aortic dissection were obtained from registers.
Increased blood Cd was associated with increased risk of incident AAA after adjustment for smoking and other established risk factors for AAA. The highest tertile of blood Cd concentrations had a rate ratio of 2.5 (95% confidence interval 1.3, 5.0) for incident AAA. Concentration of blood Cd (log transformed) was not associated with AAA in never-smokers (n = 24).
Blood Cd levels corresponding to the upper tertile of the distribution in the age- and sex-matched control group were associated with a 2.5-fold increase in rate ratio for incident AAA. This relationship was not found in the small group of never-smokers.
饮食和吸烟使普通人群接触镉（Cd），镉是一种在动脉壁中蓄积的有毒金属。在实验研究中，镉会导致平滑肌细胞增殖减少和前胶原的细胞合成减少。本研究的目的是检验血镉水平（一种有效的镉暴露测量指标）是否与腹主动脉瘤（AAA）风险增加相关。
对参加马尔默饮食与癌症研究的所有中年男性和女性（n = 30447）从1991 - 1996年的基线检查开始随访至2009年。共纳入297例AAA患者以及为每例患者随机选取的两名年龄和性别匹配的对照对象。通过电感耦合等离子体质谱法分析血镉。AAA、胸主动脉瘤和主动脉夹层的诊断从登记处获取。
在对吸烟和其他已确定的AAA风险因素进行调整后，血镉升高与AAA发病风险增加相关。血镉浓度最高三分位数组的AAA发病率比为2.5（95%置信区间1.3，5.0）。血镉浓度（对数转换）在从不吸烟者（n = 24）中与AAA无关。
年龄和性别匹配对照组中血镉水平对应分布的上三分位数与AAA发病率比增加2.5倍相关。在一小群从不吸烟者中未发现这种关系。
