Yao Zhongqiang, Yang Binhui, Liu Zhongqiu, Li Wei, He Qihua, Peng Xingchun
Department of Medical Oncology, 3201 Affiliated Hospital of Medical College of Xi'an Jiaotong University, Hanzhong, 723000, Shanxi Province, P. R. China.
Department of Centre of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei Province, P. R. China.
Oncotarget. 2017 Apr 11;8(15):25270-25278. doi: 10.18632/oncotarget.15751.
Bcl-2 is critical for tumorigenesis. However, previous studies on the association of Bcl-2 promoter polymorphisms with predisposition to different cancer types are somewhat contradictory. Therefore, we performed this meta-analysis regarding the relationship between Bcl-2 promoter single nucleotide polymorphisms (SNPs) and cancer susceptibility and prognosis. Up to August 2016, 32 original publications were identified covering two Bcl-2 promoter SNPs (rs2279115 and rs1801018). Our results showed statistically significant association between rs2279115 and cancer susceptibility and prognosis in all four genetic models but not in rs1801018. Subgroups analysis indicated that rs2279115 was associated with a significantly higher risk of cancer susceptibility in Asia but not in Caucasian. Furthermore, rs2279115 was associated with a significantly higher risk in digestive system cancer and endocrine system cancer but not in breast cancer, respiratory cancer and hematopoietic cancer. Simultaneously, rs2279115 was correlated with a significantly higher risk of cancer prognosis in Asia but not in Caucasian. Considering these promising results, rs2279115 may be a tumor marker for cancertherapy in Asia. Sensitivity analysis show four gene model were stable, and no publication bias was observed in all four gene model. Large sample size, different ethnic population and different cancer type are warranted to validate this association.
Bcl-2对肿瘤发生至关重要。然而，先前关于Bcl-2启动子多态性与不同癌症类型易感性之间关联的研究结果有些相互矛盾。因此，我们进行了这项荟萃分析，以探讨Bcl-2启动子单核苷酸多态性（SNP）与癌症易感性及预后之间的关系。截至2016年8月，共鉴定出32篇原始文献，涵盖两个Bcl-2启动子SNP（rs2279115和rs1801018）。我们的结果显示，在所有四种遗传模型中，rs2279115与癌症易感性及预后之间存在统计学上的显著关联，但rs1801018不存在这种关联。亚组分析表明，rs2279115在亚洲人群中与癌症易感性风险显著升高相关，但在白种人中并非如此。此外，rs2279115在消化系统癌症和内分泌系统癌症中与显著更高的风险相关，但在乳腺癌、呼吸道癌症和造血系统癌症中并非如此。同时，rs2279115在亚洲人群中与癌症预后风险显著升高相关，但在白种人中并非如此。鉴于这些有前景的结果，rs2279115可能是亚洲癌症治疗的一个肿瘤标志物。敏感性分析表明四种基因模型稳定，且在所有四种基因模型中均未观察到发表偏倚。需要大样本量、不同种族人群和不同癌症类型来验证这种关联。
