Zhang Jing, Yue Lei, Li Ying-Lu
Department of Clinical Laboratorial Examination, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan Province, China.
Department of Oncology, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):460-464. doi: 10.7534/j.issn.1009-2137.2017.02.027.
To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients.
The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed.
The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0.05), but there was no significant difference in EBV-DNA level between peripheral leukocytes and serum (P>0.05). The I-II stages ratio of patients in EBV group was significantly lower than that in EBV group. The CR rate and ORR in EBV group was significantly lower than those in EBV group, the 3 year OS rate and 3 year DFR in EBV group also was significantly lower than those in EBV group.
The detection of periphera blood EBV may be used as an reference indicator for anxiliary diagnosis of NK/T cell lymphoma and evaluation of prognosis for patients, thus possessing a certain value for clinical application.
