Bailey Chris, Dearden Claire, Ardeshna Kirit
Department of Haematology, Imperial College Healthcare NHS Trust, London, UK.
Department of Haemato-Oncology, Royal Marsden Hospital, London, UK.
BMJ Case Rep. 2017 Apr 26;2017:bcr-2016-219057. doi: 10.1136/bcr-2016-219057.
Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome characterised by defective cytotoxic function and hypercytokinaemia leading to macrophage expansion and haemophagocytosis. Patients often present with unexplained fevers, hepatosplenomegaly and pancytopenia, with elevation in serum ferritin and triglyceride. Acquired forms are triggered by infection, malignancy or rheumatological disorders. HLH in the setting of chronic lymphocytic leukaemia is rarely reported, however, and is usually associated with infection or as a consequence of chemotherapy. We present a case of HLH in a 64-year-old Caucasian woman with the only identified trigger being her hitherto untreated CLL.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见的、危及生命的综合征，其特征为细胞毒性功能缺陷和细胞因子血症，导致巨噬细胞增生和噬血细胞现象。患者常表现为不明原因发热、肝脾肿大和全血细胞减少，血清铁蛋白和甘油三酯升高。获得性形式由感染、恶性肿瘤或风湿性疾病引发。然而，慢性淋巴细胞白血病患者中HLH的报道很少，通常与感染或化疗有关。我们报告一例64岁白种女性患HLH的病例，唯一确定的诱因是她此前未治疗的慢性淋巴细胞白血病。
