富含脯氨酸肽对阿尔茨海默病大鼠模型的保护作用：一项电生理学研究。
Protective Effects of Proline-Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study.
作者信息
Khalaji Naser, Sarkissian John, Chavushyan Vergine, Sarkisian Vaghinak
机构信息
Department of Physiology, School of Medicine, Uremia University of Medical Sciences, Uremia, Iran.
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia.
出版信息
Basic Clin Neurosci. 2017 Jan;8(1):5-12. doi: 10.15412/J.BCN.03080101.
INTRODUCTION
Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-β (Aβ).
METHODS
Experiments were carried out on 24 adult, male Albino rats (average weight: 230±30 g). The animals were randomly divided into 3 groups (control, Aβ, and Aβ plus PRP-1). Electrophysiological patterns of hippocampal neurons in response to stimulation of entorhinal cortex (EC) with high frequency stimulation (50 Hz) were studied.
RESULTS
It was found that Aβ (25-35) suppresses the electrical activity of hippocampal neurons. The PRP-1 would return this activity to normal levels.
CONCLUSION
In general, PRP-1 has protective effect against AD-related alterations induced by amyloid peptides. This protective effect is probably due to stimulation of the immune and glia system.
引言
阿尔茨海默病（AD）是老年人中最常见的痴呆形式，它会缓慢破坏记忆和认知功能。这种疾病无法治愈，并会导致大脑出现显著的结构和功能异常。为了促进对该疾病的治疗，我们旨在研究脑室内注射淀粉样β蛋白（Aβ）后，下丘脑富含脯氨酸的肽（PRP-1）对海马（HP）神经元的作用及其恢复动态。
方法
对24只成年雄性白化大鼠（平均体重：230±30克）进行实验。将动物随机分为3组（对照组、Aβ组和Aβ加PRP-1组）。研究了海马神经元在高频刺激（50赫兹）内嗅皮质（EC）时的电生理模式。
结果
发现Aβ（25-35）抑制海马神经元的电活动。PRP-1可使这种活动恢复到正常水平。
结论
总体而言，PRP-1对淀粉样肽诱导的与AD相关的改变具有保护作用。这种保护作用可能是由于刺激了免疫和神经胶质系统。
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