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长时程增强在 CA3-CA1 海马突触中的作用，特别关注衰老、疾病和应激。

Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.

机构信息

Department of Neuroscience, McKnight Brain Institute, University of Florida Gainesville, FL, USA.

出版信息

Front Aging Neurosci. 2011 May 20;3:7. doi: 10.3389/fnagi.2011.00007. eCollection 2011.

DOI:10.3389/fnagi.2011.00007
PMID:21647396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3102214/
Abstract

Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.

摘要

在过去的四十年里，哺乳动物中枢神经系统的突触可塑性一直是研究的热点。长时程增强（LTP）是突触可塑性的主要表现形式，是在给予短暂的高频电刺激后，兴奋性突触传递效率的一种活动依赖性的持久增强。LTP 被认为是参与学习的细胞机制的主要候选者，并提供了一个关于记忆是如何构建的有吸引力的假设。有许多关于 LTP 的优秀的全文综述发表；本综述旨在对海马体 LTP 的研究结果进行概述，特别强调与衰老、疾病和心理创伤有关的研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/f13830993e70/fnagi-03-00007-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/e5368200f881/fnagi-03-00007-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/d1eedf594b05/fnagi-03-00007-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/f13830993e70/fnagi-03-00007-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/e5368200f881/fnagi-03-00007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/f9b456819aba/fnagi-03-00007-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/d1eedf594b05/fnagi-03-00007-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/3102214/f13830993e70/fnagi-03-00007-g004.jpg

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