微小RNA 21在肥胖糖尿病患者的脂肪组织中上调。
MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects.
作者信息
Guglielmi Valeria, D'Adamo Monica, Menghini Rossella, Cardellini Marina, Gentileschi Paolo, Federici Massimo, Sbraccia Paolo
机构信息
Department of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy.
Obesity Center and Internal Medicine Unit, University Hospital Policlinico Tor Vergata, Rome, Italy.
出版信息
Nutr Healthy Aging. 2017 Mar 31;4(2):141-145. doi: 10.3233/NHA-160020.
We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.
我们研究了16名接受减肥手术的肥胖受试者网膜脂肪组织（OAT）和皮下脂肪组织（SAT）中miR21的表达情况。根据2型糖尿病（T2D）的存在情况，将患者分为两个年龄和体重指数匹配的组。miR21在OAT和SAT中的表达没有差异。然而，T2D患者脂肪组织中miR21的表达增加了两倍。因此，在非糖尿病超重受试者的原代脂肪细胞培养中，暴露于高糖和胰岛素24小时后，miR21表达增加。总之，在从肥胖到T2D的病理生理进展过程中，miR21似乎与胰岛素抵抗恶化有关。
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