小于胎龄早产伴胎儿生长受限男婴出生后早期尿中促性腺激素水平
Gonadotropin levels in urine during early postnatal period in small for gestational age preterm male infants with fetal growth restriction.
作者信息
Nagai S, Kawai M, Myowa-Yamakoshi M, Morimoto T, Matsukura T, Heike T
机构信息
Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Graduate School of Education, Kyoto University, Kyoto, Japan.
出版信息
J Perinatol. 2017 Jul;37(7):843-847. doi: 10.1038/jp.2017.55. Epub 2017 Apr 27.
OBJECTIVE
The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development.
STUDY DESIGN
We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test.
RESULTS
A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P=0.004 and P=0.006, respectively) than AGA infants.
CONCLUSION
Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life.
目的
本研究的目的是评估小于胎龄（SGA）男婴在出生后最初几个月下丘脑 - 垂体 - 性腺轴再激活时的促性腺激素浓度，这对生殖器发育很重要。
研究设计
2013年至2014年期间，我们在京都大学医院对15名SGA和15名适于胎龄（AGA）的早产男婴进行了前瞻性检查。在出生后第7天至168天的系列尿液样本中测量促性腺激素浓度（促黄体生成素（LH）和促卵泡生成素（FSH）），并使用Mann - Whitney检验比较SGA和AGA婴儿之间的差异。
结果
纵向分析显示，SGA婴儿的LH浓度高于AGA婴儿，FSH浓度低于AGA婴儿（P分别为0.004和0.006）。
结论
因胎儿生长受限出生时为SGA的男婴在出生后的最初几个月存在促性腺激素分泌异常。
Zotero 插件