a Department of Oncology, Xiangya Hospital , Central South University , Changsha , Hunan Province , China.
b Department of Orthopedics, Xiangya Hospital , Central South University , Changsha , Hunan Province , China.
Clin Exp Hypertens. 2017;39(3):235-240. doi: 10.1080/10641963.2016.1246559.
The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population.
Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted.
A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G>A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant.
The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.
CYP3A5 基因多态性与中国人高血压的关系尚不清楚。我们探讨了 CYP3A5（rs776746）基因与中国汉族人群高血压的关系。
采用病例对照设计，2015 年 7 月至 12 月期间，我们从南方医科大学第三附属医院招募了 340 例病例和 254 例对照。我们使用标准化问卷收集年龄、性别、吸烟、饮酒、高血压家族史和体育锻炼等数据。测量身高和体重，并计算体重/身高的体重指数（BMI）。血压测量前休息 5 分钟，至少间隔 15 秒测量 3 次，取平均值作为最终血压。进行临床检查。
共有 594 名参与者（病例 340 例，对照 254 例）纳入分析。CYP3A5 G>A 多态性的基因型频率符合 Hardy-Weinberg 平衡。病例组的基因型频率分别为 38.8%（GA，132 例）、42.9%（GG，146 例）和 18.2%（AA，62 例）。病例组和对照组之间的基因型差异具有统计学意义。在调整模型 2 中的潜在混杂因素后，AA 基因型与高血压的发病风险升高相关。吸烟和 CYP3A5 基因型之间没有交互作用，而饮酒和 CYP3A5 基因型之间存在交互作用。
CYP3A5 基因可能与中国汉族人群的高血压风险相关，这种作用可能因饮酒而加剧。
