Department of Polymer Science, The University of Akron, Akron, OH 44325-3909, USA.
Department of Polymer Science, The University of Akron, Akron, OH 44325-3909, USA.
J Colloid Interface Sci. 2017 Sep 1;501:150-155. doi: 10.1016/j.jcis.2017.04.044. Epub 2017 Apr 17.
We demonstrate the surfactant-free production of polymer nanoparticles using a continuous membrane-based tangential flow cell. Co-current streams of water and polymethylmethacrylate (PMMA)/acetone/water solution were separated by a porous regenerated cellulose (RC) membrane. The water concentration in the PMMA solution was adjusted so that as additional water diffused through the RC membrane, the PMMA solution composition crossed the two phase boundary to precipitate PMMA nanoparticles. The size of these nanoparticles varied with the concentration of the PMMA feed and the amount of water diffusing across the membrane. The size distribution of PMMA particles produced in a continuous flow membrane cell was much narrower than those produced by drop-wise water addition or batch dialysis precipitation of PMMA particles. A continuous production of polymer nanoparticles of high purity and narrow polydispersity are important requirements for biomedical applications such as delivering therapeutics.
我们展示了一种使用连续膜式切向流细胞无表面活性剂生产聚合物纳米粒子的方法。水和聚甲基丙烯酸甲酯（PMMA）/丙酮/水溶液的同向流被多孔再生纤维素（RC）膜隔开。调整 PMMA 溶液中的水浓度，以便当更多的水通过 RC 膜扩散时，PMMA 溶液的组成越过两相边界沉淀出 PMMA 纳米粒子。这些纳米粒子的大小随 PMMA 进料的浓度和穿过膜扩散的水量而变化。在连续流动膜细胞中生产的 PMMA 颗粒的尺寸分布比通过逐滴添加水或间歇透析沉淀 PMMA 颗粒生产的颗粒要窄得多。对于生物医学应用，如输送治疗剂，连续生产高纯度和窄多分散性的聚合物纳米粒子是重要的要求。
