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Safety profile of EGFR-targeted hybrid vector system composed of PAMAM dendrimer and oncolytic adenovirus.

作者信息

Yoon A-Rum, Kasala Dayananda, Hong Jinwoo, Yun Chae-Ok

机构信息

Department of Bioengineering College of Engineering Hanyang University, Seoul 133-791, Korea.

出版信息

J Thorac Dis. 2017 Mar;9(3):E335-E336. doi: 10.21037/jtd.2017.03.44.

DOI:10.21037/jtd.2017.03.44
PMID:28449534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5394079/
Abstract
摘要

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本文引用的文献

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PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery.聚乙二醇化聚酰胺-胺树枝状大分子:增强疗效并减轻毒性以实现有效的抗癌药物和基因递送
Acta Biomater. 2016 Oct 1;43:14-29. doi: 10.1016/j.actbio.2016.07.015. Epub 2016 Jul 12.
2
Antitumor effect and safety profile of systemically delivered oncolytic adenovirus complexed with EGFR-targeted PAMAM-based dendrimer in orthotopic lung tumor model.系统递送与 EGFR 靶向的 PAMAM 树状聚合物复合的溶瘤腺病毒在原位肺肿瘤模型中的抗肿瘤作用和安全性特征。
J Control Release. 2016 Jun 10;231:2-16. doi: 10.1016/j.jconrel.2016.02.046. Epub 2016 Mar 4.
3
Potent antitumor effect of neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist in an orthotopic pancreatic tumor model.神经降压素受体靶向共表达decorin 和 Wnt 拮抗剂的溶瘤腺病毒在原位胰腺肿瘤模型中的强效抗肿瘤作用。
J Control Release. 2015 Dec 28;220(Pt B):766-82. doi: 10.1016/j.jconrel.2015.10.015. Epub 2015 Oct 22.
4
Safety profiles and antitumor efficacy of oncolytic adenovirus coated with bioreducible polymer in the treatment of a CAR negative tumor model.生物可还原聚合物包被的溶瘤腺病毒治疗CAR阴性肿瘤模型的安全性及抗肿瘤疗效
Biomacromolecules. 2015 Jan 12;16(1):87-96. doi: 10.1021/bm501116x. Epub 2014 Dec 1.
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The importance of animal models in tumor immunity and immunotherapy.动物模型在肿瘤免疫和免疫治疗中的重要性。
Curr Opin Genet Dev. 2014 Feb;24:46-51. doi: 10.1016/j.gde.2013.11.008. Epub 2013 Dec 29.
6
PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation.聚乙二醇化 PAMAM 树枝状聚合物-阿霉素偶联物:体外评价及体内肿瘤蓄积。
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Current status of polymeric gene delivery systems.聚合物基因递送系统的当前状况。
Adv Drug Deliv Rev. 2006 Jul 7;58(4):467-86. doi: 10.1016/j.addr.2006.03.007. Epub 2006 Jun 15.
8
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