• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微小RNA-23b调控宫颈癌干细胞中醛脱氢酶1A1的表达。

MiR-23b controls ALDH1A1 expression in cervical cancer stem cells.

作者信息

Wang Weiwen, Li Yang, Liu Na, Gao Yu, Li Long

机构信息

Department of Gynecology and Obstetrics, First Affiliated Hospital, Xi'an Jiaotong University, 277 West Yanta Road, 710061, Xi'an, China.

Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

出版信息

BMC Cancer. 2017 Apr 27;17(1):292. doi: 10.1186/s12885-017-3192-x.

DOI:10.1186/s12885-017-3192-x
PMID:28449663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5408421/
Abstract

BACKGROUND

Cancer stem cells has been widely investigated due to its essential role in cancer progression and drug resistance. Here, we try to find a new therapeutic target for cervical cancer stem cells.

METHODS

We detected ALDH1A1-associated miRNAs expression in our isolated tumorspheres and their corresponding parental cells. Sphere formation assay was also used to determine stemness after cells were manipulated with miR-23b plasmid or miR-23b inhibitor.

RESULTS

We found that miR-23b was under-expressed in cervical cancer stem cells to maintain high levels of ALDH1A1. Introduction of miR-23b into cervical cancer cells could alter stemness and cisplatin sensitivity.

CONCLUSIONS

miR-23b plays key role in maintaining stemness of cervical cancer stem cells and can be developed as therapeutic target to better fight against cervical cancer.

摘要

背景

癌症干细胞因其在癌症进展和耐药性中的关键作用而受到广泛研究。在此，我们试图寻找一种针对宫颈癌干细胞的新治疗靶点。

方法

我们检测了在我们分离的肿瘤球及其相应亲代细胞中与醛脱氢酶1家族成员A1（ALDH1A1）相关的微小RNA（miRNA）表达。在用miR-23b质粒或miR-23b抑制剂处理细胞后，还使用成球试验来确定干性。

结果

我们发现miR-23b在宫颈癌干细胞中低表达，以维持高水平的ALDH1A1。将miR-23b导入宫颈癌细胞可改变干性和顺铂敏感性。

结论

miR-23b在维持宫颈癌干细胞干性中起关键作用，可作为治疗靶点开发，以更好地对抗宫颈癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/d3819e5ab56e/12885_2017_3192_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/13969e7b31df/12885_2017_3192_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/727ddf438999/12885_2017_3192_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/b00728cfe9b4/12885_2017_3192_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/d3819e5ab56e/12885_2017_3192_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/13969e7b31df/12885_2017_3192_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/727ddf438999/12885_2017_3192_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/b00728cfe9b4/12885_2017_3192_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910f/5408421/d3819e5ab56e/12885_2017_3192_Fig4_HTML.jpg

相似文献

1
MiR-23b controls ALDH1A1 expression in cervical cancer stem cells.微小RNA-23b调控宫颈癌干细胞中醛脱氢酶1A1的表达。
BMC Cancer. 2017 Apr 27;17(1):292. doi: 10.1186/s12885-017-3192-x.
2
MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1.微小RNA-519d通过下调髓细胞白血病序列1（MCL-1）的表达来抑制乳腺癌干细胞中的顺铂耐药性。
Oncotarget. 2017 Mar 28;8(13):22003-22013. doi: 10.18632/oncotarget.15781.
3
Suppression of long noncoding RNA NCK1-AS1 increases chemosensitivity to cisplatin in cervical cancer.长链非编码 RNA NCK1-AS1 的抑制可增加宫颈癌对顺铂的化疗敏感性。
J Cell Physiol. 2019 Apr;234(4):4302-4313. doi: 10.1002/jcp.27198. Epub 2018 Sep 17.
4
MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD.MicroRNA-181a 通过靶向 PRKCD 增强人宫颈鳞状细胞癌细胞对顺铂的化疗耐药性。
Exp Cell Res. 2014 Jan 1;320(1):12-20. doi: 10.1016/j.yexcr.2013.10.014. Epub 2013 Oct 31.
5
MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1.miR-1284 通过下调 HMGB1 增强宫颈癌对顺铂的敏感性。
Biomed Pharmacother. 2018 Nov;107:997-1003. doi: 10.1016/j.biopha.2018.08.059. Epub 2018 Aug 23.
6
MicroRNA-7-5p Promotes Cisplatin Resistance of Cervical Cancer Cells and Modulation of Cellular Energy Homeostasis by Regulating the Expression of the PARP-1 and BCL2 Genes.microRNA-7-5p 通过调节 PARP-1 和 BCL2 基因的表达促进宫颈癌顺铂耐药并调节细胞能量稳态。
Med Sci Monit. 2018 Sep 16;24:6506-6516. doi: 10.12659/MSM.910969.
7
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition.醛脱氢酶1 A1抑制可消除头颈部癌中癌症干细胞介导的获得性化疗耐药性。
Mol Carcinog. 2017 Feb;56(2):694-711. doi: 10.1002/mc.22526. Epub 2016 Aug 4.
8
Cancer-Derived Exosomal miR-651 as a Diagnostic Marker Restrains Cisplatin Resistance and Directly Targets ATG3 for Cervical Cancer.肿瘤衍生的外泌体 miR-651 作为一种诊断标志物抑制顺铂耐药并直接靶向 ATG3 治疗宫颈癌。
Dis Markers. 2021 Sep 15;2021:1544784. doi: 10.1155/2021/1544784. eCollection 2021.
9
MiR-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer.微小RNA-218抑制宫颈癌肿瘤生长并增强对顺铂的化疗敏感性。
Int J Mol Sci. 2012 Nov 28;13(12):16053-64. doi: 10.3390/ijms131216053.
10
Long Noncoding RNA GAS5, Which Acts as a Tumor Suppressor via microRNA 21, Regulates Cisplatin Resistance Expression in Cervical Cancer.长链非编码RNA GAS5通过微小RNA 21发挥肿瘤抑制作用，调控宫颈癌顺铂耐药表达。
Int J Gynecol Cancer. 2017 Jul;27(6):1096-1108. doi: 10.1097/IGC.0000000000001028.

引用本文的文献

1
MicroRNAs: Novel clinical biomarkers for cancer radiotherapy (Review).微小RNA：癌症放疗的新型临床生物标志物（综述）
Mol Med Rep. 2025 Sep;32(3). doi: 10.3892/mmr.2025.13619. Epub 2025 Jul 11.
2
, and are overexpressed in cervical cancer tissues and the miR‑23b‑3p/HMGB2 axis regulates cell migration and invasion.在宫颈癌组织中高表达，且miR-23b-3p/HMGB2轴调节细胞迁移和侵袭。
Mol Med Rep. 2025 Sep;32(3). doi: 10.3892/mmr.2025.13600. Epub 2025 Jun 27.
3
Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia.

本文引用的文献

1
MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression.微小RNA-23b靶向细胞周期蛋白G1并抑制卵巢癌的发生和发展。
J Exp Clin Cancer Res. 2016 Feb 13;35:31. doi: 10.1186/s13046-016-0307-1.
2
Cancer statistics, 2016.癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
3
microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4.微小RNA-150通过靶向FOXO4促进宫颈癌细胞的生长和存活。
研究 microRNA 与 ALDH1A1 的生物学联系，揭示了急性髓细胞白血病临床前测试的候选物。
Int J Oncol. 2024 Dec;65(6). doi: 10.3892/ijo.2024.5703. Epub 2024 Nov 8.
4
Understanding the autophagic functions in cancer stem cell maintenance and therapy resistance.理解自噬在肿瘤干细胞维持和治疗抵抗中的作用。
Expert Rev Mol Med. 2024 Oct 8;26:e23. doi: 10.1017/erm.2024.23.
5
Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer.植物源天然产物抗耐药性癌症的研究进展。
Nutrients. 2024 Mar 11;16(6):797. doi: 10.3390/nu16060797.
6
Cancer stem cells: a target for overcoming therapeutic resistance and relapse.癌症干细胞：克服治疗抗性和复发的靶点。
Cancer Biol Med. 2023 Dec 29;20(12):985-1020. doi: 10.20892/j.issn.2095-3941.2023.0333.
7
ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism.癌症中的乙醛脱氢酶1A1：双向功能、耐药性及调控机制
Front Oncol. 2022 Jun 22;12:918778. doi: 10.3389/fonc.2022.918778. eCollection 2022.
8
miR-23b-3p rescues cognition in Alzheimer's disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways.微小RNA-23b-3p通过糖原合酶激酶-3β信号通路减少tau蛋白磷酸化和细胞凋亡，从而挽救阿尔茨海默病中的认知功能。
Mol Ther Nucleic Acids. 2022 Apr 18;28:539-557. doi: 10.1016/j.omtn.2022.04.008. eCollection 2022 Jun 14.
9
Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review.癌症干细胞及其在宫颈癌中的可能意义：简短综述。
Int J Mol Sci. 2022 May 5;23(9):5167. doi: 10.3390/ijms23095167.
10
AHRR contributes to inflammatory lymphangiogenesis by activating the EPAS1/VEGFD signaling axis in head and neck cancer.芳烃受体阻抑蛋白（AHRR）通过激活头颈癌中的内皮 PAS 结构域蛋白 1（EPAS1）/血管内皮生长因子 D（VEGFD）信号轴促进炎症性淋巴管生成。
Am J Cancer Res. 2022 Feb 15;12(2):537-548. eCollection 2022.
BMC Mol Biol. 2015 Dec 29;16:24. doi: 10.1186/s12867-015-0052-6.
4
miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer.miR-23b作为一种潜在的肿瘤抑制因子及其在宫颈癌中受DNA甲基化的调控
Infect Agent Cancer. 2015 Nov 30;10:42. doi: 10.1186/s13027-015-0037-6. eCollection 2015.
5
Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications.表皮生长因子受体通路突变及表达谱在宫颈鳞状细胞癌中的研究：治疗意义
J Transl Med. 2015 Jul 25;13:244. doi: 10.1186/s12967-015-0611-0.
6
The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis.Notch2信号通路与miR-23b在调控胃癌发生中的相互调节环路
Oncotarget. 2015 Jul 20;6(20):18012-26. doi: 10.18632/oncotarget.4000.
7
Cervical cancer stem cells: opportunities and challenges.宫颈癌干细胞：机遇与挑战
J Cancer Res Clin Oncol. 2015 Nov;141(11):1889-97. doi: 10.1007/s00432-014-1905-y. Epub 2015 Jan 7.
8
The role of signaling pathways in cervical cancer and molecular therapeutic targets.信号通路在宫颈癌中的作用及分子治疗靶点
Arch Med Res. 2014 Oct;45(7):525-39. doi: 10.1016/j.arcmed.2014.10.008. Epub 2014 Nov 11.
9
Monitoring treatment response in patients undergoing chemoradiotherapy for locally advanced uterine cervical cancer by additional diffusion-weighted imaging: A systematic review.通过额外的扩散加权成像监测局部晚期子宫颈癌患者放化疗的治疗反应：一项系统评价。
J Magn Reson Imaging. 2015 Sep;42(3):572-94. doi: 10.1002/jmri.24784. Epub 2014 Oct 24.
10
Regulation of microRNA biogenesis.miRNA 生物发生的调控。
Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24. doi: 10.1038/nrm3838. Epub 2014 Jul 16.