Sernatinger J, Hoffman A, Hardman D, Kane J P, Levy J A
Cancer Research Institute, Department of Medicine, School of Medicine, University of California, San Francisco 94143.
J Gen Virol. 1988 Oct;69 ( Pt 10):2657-61. doi: 10.1099/0022-1317-69-10-2657.
We examined the properties of the mouse serum lipoprotein responsible for specific neutralization of the endogenous mouse xenotropic (X-tropic) type C retrovirus. The anti-X-tropic virus activity of the mouse lipoprotein neutralizing factor (NF) could not be blocked by sugars or lectins. Moreover, neutralization did not involve rupture of the virion core. Sucrose density gradient analysis of X-tropic virus mixed with various lipoprotein preparations demonstrated that the binding of complete virions to NF is associated with the neutralization.
我们研究了负责特异性中和内源性小鼠嗜异性（X-嗜性）C型逆转录病毒的小鼠血清脂蛋白的特性。小鼠脂蛋白中和因子（NF）的抗X-嗜性病毒活性不能被糖类或凝集素阻断。此外，中和作用不涉及病毒粒子核心的破裂。对与各种脂蛋白制剂混合的X-嗜性病毒进行蔗糖密度梯度分析表明，完整病毒粒子与NF的结合与中和作用相关。
