McKernan P D, Schare M B
Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, MI 48072.
J Reprod Med. 1988 Jul;33(7):667-70.
Although enteroviral meningitis complicating pregnancy is a rare occurrence, it can lead to serious antenatal and neonatal complications. The majority of neonatal enteroviral infections are transmitted from a perinatally infected mother. We treated a woman for type B-2 coxsackievirus meningitis diagnosed in pregnancy. Three weeks after the acute maternal infection was diagnosed, a preterm neonate with no evidence of enteroviral infection was delivered. The neonate had no detectable IgM or virus-specific IgG at birth and later demonstrated IgG seroconversion to the coxsackievirus isolated from the mother. Intrapartum or postpartum exposure to the coxsackievirus is the suspected mode of transmission. Other factors in addition to passively acquired virus-specific IgG may offer neonatal protection to fetuses exposed to perinatal enteroviral infections.
尽管肠道病毒脑膜炎并发妊娠较为罕见，但它可导致严重的产前和新生儿并发症。大多数新生儿肠道病毒感染是由围产期感染的母亲传播的。我们治疗了一名在孕期被诊断为B - 2型柯萨奇病毒脑膜炎的女性。在诊断出急性母体感染三周后，分娩出一名无肠道病毒感染证据的早产儿。该新生儿出生时未检测到IgM或病毒特异性IgG，后来显示针对从母亲分离出的柯萨奇病毒的IgG血清转化。产时或产后接触柯萨奇病毒是疑似传播方式。除了被动获得的病毒特异性IgG外，其他因素可能为暴露于围产期肠道病毒感染的胎儿提供新生儿保护。
