Deroose C M, Stroobants S, Liu Y, Shankar L K, Bourguet P
Nuclear Medicine, UZ Leuven, Leuven, Belgium.
Nuclear Medicine & Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Eur J Nucl Med Mol Imaging. 2017 Aug;44(Suppl 1):32-40. doi: 10.1007/s00259-017-3689-1. Epub 2017 Apr 27.
Molecular imaging with PET has emerged as a powerful imaging tool in the clinical care of oncological patients. Assessing therapy response is a prime application of PET and so the integration of PET into multicentre trials can offer valuable scientific insights and shape future clinical practice. However, there are a number of logistic and methodological challenges that have to be dealt with. These range from availability and regulatory compliance of the PET radiopharmaceutical to availability of scan time for research purposes. Standardization of imaging and reconstruction protocols, quality control, image processing and analysis are of paramount importance. Strategies for harmonization of the final image and the quantification result are available and can be implemented within the scope of multicentre accreditation programmes. Data analysis can be performed either locally or by centralized review. Response assessment can be done visually or using more quantitative approaches, depending on the research question. Large-scale real-time centralized review can be achieved using web-based solutions. Specific challenges for the future are inclusion of PET/MRI scanners in multicentre trials and the incorporation of radiomic analyses. Inclusion of PET in multicentre trials is a necessity to guarantee the further development of PET for routine clinical care and may yield very valuable scientific insights.
正电子发射断层扫描（PET）分子成像已成为肿瘤患者临床护理中一种强大的成像工具。评估治疗反应是PET的主要应用，因此将PET纳入多中心试验可以提供有价值的科学见解并塑造未来的临床实践。然而，有许多后勤和方法学方面的挑战需要应对。这些挑战从PET放射性药物的可用性和法规遵从性到用于研究目的的扫描时间的可用性。成像和重建协议的标准化、质量控制、图像处理和分析至关重要。最终图像和定量结果的协调策略是可用的，并且可以在多中心认证计划的范围内实施。数据分析可以在本地进行，也可以通过集中审查进行。根据研究问题，反应评估可以通过视觉方式或使用更定量的方法进行。使用基于网络的解决方案可以实现大规模实时集中审查。未来的具体挑战包括将PET/MRI扫描仪纳入多中心试验以及纳入放射组学分析。将PET纳入多中心试验是保证PET进一步发展用于常规临床护理的必要条件，并且可能产生非常有价值的科学见解。
