Davies A O
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Metabolism. 1988 Oct;37(10):916-8. doi: 10.1016/0026-0495(88)90146-1.
The purpose of this study was to quantitatively examine to what extent acute exertion diminishes the activity of beta-adrenergic receptors through diminishing coupling. Normal neutrophil membrane preparations containing beta 2-adrenergic receptors were obtained from healthy human volunteers, then exposed to autologous venous plasma obtained before and after acute forearm exertion. There was an acute, dramatic diminution in coupling (P less than .003) after only a few minutes of exercise. Preexertion plasma had no significant effect upon coupling. Substantial diminution in beta-adrenergic receptor sensitivity is thus acutely demonstrable in this model which serves as a model for both metabolic acidosis and acute exertion.
本研究的目的是定量检测急性运动通过减弱偶联作用在多大程度上降低β-肾上腺素能受体的活性。从健康人类志愿者身上获取含有β2-肾上腺素能受体的正常中性粒细胞膜制剂，然后将其暴露于急性前臂运动前后获取的自体静脉血浆中。仅几分钟的运动后，偶联作用就出现了急性、显著的减弱（P<0.003）。运动前血浆对偶联作用无显著影响。因此，在这个作为代谢性酸中毒和急性运动模型的实验中，可以明确证明β-肾上腺素能受体敏感性会急性降低。
